Synthesis and conformational analysis of 1,3-azasilinanes
1-Isopropyl-3-methyl-3-phenyl-1,3-azasilinane 1 and 1-isopropyl-3,3- dimethyl-1,3-azasilinane 2 were synthesized and a detailed analysis of their NMR spectra, conformational equilibria and ring inversion processes is presented. Low temperature 1/sup
Shainyan, Bagrat A.,Kirpichenko, Svetlana V.,Kleinpeter, Erich
experimental part
p. 7494 - 7501
(2012/09/21)
Synthesis of L-ascorbic acid derivatives as potential bone remodeling agents taking advantage of the Mitsunobu reaction
The synthesis of ascorbic acid derivatives 7a-d is described. Starting from alkenylacetates 1a-d subjected to a hydrosilylation reaction, the resulting hydroxy chloro silanes 3a-d were obtained in high yield. The latter compounds were reacted with potassium phthalimide followed with hydrazine hydrate to give the amino silanols 5a-d. Ascorbic acid was then alkylated on its 3-hydroxy position to give 7a-d by means of a Mitsunobu reaction.
Benzamide derivatives of the formula : wherein R1 is optionally substituted alkyl optionally containing double or triple bonds or cycloalkyl rings, which is interrupted by silicon, and optionally interrupted by a hetero atom, and/or by sulphinyl or sulpho
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(2008/06/13)
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