181995-80-2

Basic information

• Product Name: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methoxy-(9CI)
• Synonyms: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methoxy-(9CI)
• CAS NO: 181995-80-2
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.22578
• Product Categories: BENZIMIDAZOLE
• Mol File: 181995-80-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methoxy-(9CI)(181995-80-2)
• EPA Substance Registry System: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methoxy-(9CI)(181995-80-2)

Safety Data

• Hazardous Substances Data: 181995-80-2(Hazardous Substances Data)

Upstream product

• 1248473-29-1 2-cyclopropyl-5-methoxy-1H-benzimidazole 
• 181995-78-8 1-(4-methoxy-2-nitrophenyl)pyrrolidine 
• 5344-78-5 4-bromo-3-nitroanizole 
• 181995-79-9 N-(5-Methoxy-2-pyrrolidin-1-yl-phenyl)-acetamide 

Relevant articles and documents

Greener synthesis using hydrogen peroxide in ethyl acetate of alicyclic ring-fused benzimidazoles and anti-tumour benzimidazolequinones

Environmentally-friendly and cost effective hydrogen peroxide in ethyl acetate was used to prepare in high yields pyrrolo[1,2-a]benzimidazoles from commercial o-(pyrrolidin-1-yl)anilines without the requirement for organic-aqueous extraction and chromatography. Six, seven and eight membered ring-fused analogues were similarly obtained in high yields with methanesulfonic acid required for the pyrido[1,2-a]benzimidazole. Anti-tumour benzimidazolequinone derivatives were obtained in high yield via the cyclization of 3,6-dimethoxy-2-(cycloamino)anilines.

Synthesis of condensed heterocycles via cyclopropylimine rearrangement of cyclopropylazoles

Thermal cyclopropylimine rearrangement of cyclopropylazoles into condensed heterocycles and factors affecting the regioselectivity and conversion are reported. A method of conducting the reaction in the absence of solvents is developed. A series of 2-cyclopropylazoles, including novel examples, is synthesized and their transformations into the corresponding condensed heterocyclic compounds (2,3-dihydro-1H-pyrroles and 6,7-dihydro-5H-pyrrolo[2,1- b]thiazolium salts) are studied.

Chemistry of the pyrrolo[1,2-a]benzimidazole antitumor agents: Influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II

This study addresses the influence the 7-substituent on the cytotoxicity of pyrrolo[1,2-a]benzimidazole quinones possessing a 6-aziridinyl group (PBIs) and a 6-acetamido group (APBIs). Reduction of a PBI to the aziridinyl hydroquinone results in both nucl