A simple strategy for styryl sulfonyl ethynylogues and 1,4-diarylbut-1-en-3-ynes
A general and simple strategy for 2-arylethenyl-2'-arylethynyl sulfones (9) and 1,4-diarylbut-1d-en-3-ynes (10) has been developed by the lability of carbon-heteroatom bond in heterocycles, 1,2,3-selenadiazole (3) as the basis.
Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase
Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.
Casara,Ganzhorn,Philippo,Chanal,Danzin
p. 393 - 396
(2007/10/03)
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