182281-01-2

Basic information

• Product Name: 4-(2-Tetrahydropyranyloxy)phenylboronic acid
• Synonyms: AKOS BRN-0040;4-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID;4-HYDROXYPHENYLBORONIC ACID 2-TETRAHYDROPYRANYL ETHER;4-HYDROXYPHENYLBORONIC ACID THP ETHER;4-HYDROXYBENZENEBORONIC ACID THP ETHER;4-(2-TETRAHYDROPYRANYLOXY)PHENYLBORONIC ACID;4-Hydroxyphenylboronic;4-HYDROXYPHENYLBORONIC ACID THP ETHER 95+%
• CAS NO: 182281-01-2
• Molecular Formula: C₁₁H₁₅BO₄
• Molecular Weight: 222.05
• EINECS: 145-852-6
• Product Categories: Substituted Boronic Acids;Boronic acids;Aryl;Boronic acid;Organoborons;CHIRAL CHEMICALS;Aryl Boronic Acids;Boronic Acids and Derivatives;Monosubstituted Aryl Boronic Acids;Chemical Synthesis;New Products for Chemical Synthesis;Organometallic Reagents;NULL
• Mol File: 182281-01-2.mol

Chemical Properties

• Melting Point: 117-124 °C
• Boiling Point: 411.3 °C at 760 mmHg
• Flash Point: 202.5 °C
• Appearance: off-white to beige crystalline powder
• Density: 1.21 g/cm³
• Vapor Pressure: 1.68E-07mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 8.63±0.16(Predicted)
• CAS DataBase Reference: 4-(2-Tetrahydropyranyloxy)phenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Tetrahydropyranyloxy)phenylboronic acid(182281-01-2)
• EPA Substance Registry System: 4-(2-Tetrahydropyranyloxy)phenylboronic acid(182281-01-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-36/38
• Safety Statements: 36/37/39-26-37/39-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 182281-01-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Tetrahydropyranyloxy)phenylboronic acid is used as a reagent for the synthesis of dichloracetamide analogs, which display high anti-cancer activity. These analogs have the potential to be developed into effective pharmaceuticals for the treatment of various types of cancer.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(2-Tetrahydropyranyloxy)phenylboronic acid is utilized in the Suzuki reaction, a widely used method for the formation of carbon-carbon bonds. This reaction is essential in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Electronics Industry:
4-(2-Tetrahydropyranyloxy)phenylboronic acid is also used in the synthesis of organic semiconductors, which are crucial components in the development of electronic devices such as organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs), and organic photovoltaics (OPVs). These organic semiconductors offer advantages such as flexibility, lightweight, and the potential for low-cost manufacturing processes.

InChI:InChI=1/C11H15BO4/c13-12(14)9-4-6-10(7-5-9)16-11-3-1-2-8-15-11/h4-7,11,13-14H,1-3,8H2

Upstream product

• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 121-43-7 Trimethyl borate 
• 594-19-4 tert.-butyl lithium 
• 5419-55-6 Triisopropyl borate 
• 7732-18-5 water 
• 110-87-2 3,4-dihydro-2H-pyran 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 150-46-9 triethyl borate 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 352025-57-1 6-{4-[(Tetrahydropyran-2-yl)oxy]phenyl}-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 1048958-30-0 C₆₄H₆₂N₄O₄ 
• 1164223-73-7 5-bromo-5''-[4-(OTHP)phenyl]-2,2':6'-2''-terpyridine 
• 1202451-94-2 5-bromo-5'-(4-(OTHP)phenyl)-2,2'-bipyridine 
• 1222858-35-6 C₂₂H₁₈O₃S 
• 1135316-02-7 C₂₃H₂₀O₄S 
• 1135317-08-6 C₂₃H₂₀O₄S 
• 1222770-72-0 C₂₂H₁₈O₃S 
• 1261352-31-1 C₂₂H₁₈O₃S 
• 1135317-03-1 3-(4-hydroxyphenyl)-5-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 1401811-96-8 5-(3-{[4-(6-fluoro-3-methylquinolin-2-yl)phenoxy]methyl}-1-methyl-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one 

Relevant articles and documents

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