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182495-82-5

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

    Cas No: 182495-82-5

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  • 182495-82-5 Structure

  • Basic information

    1. Product Name: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine
    2. Synonyms: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine
    3. CAS NO:182495-82-5
    4. Molecular Formula: C38H36FN3O7
    5. Molecular Weight: 665.71
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 182495-82-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.29±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 8.54±0.40(Predicted)
    10. CAS DataBase Reference: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine(182495-82-5)
    12. EPA Substance Registry System: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine(182495-82-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 182495-82-5(Hazardous Substances Data)

182495-82-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 182495-82-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,4,9 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 182495-82:
(8*1)+(7*8)+(6*2)+(5*4)+(4*9)+(3*5)+(2*8)+(1*2)=165
165 % 10 = 5
So 182495-82-5 is a valid CAS Registry Number.

182495-82-5Downstream Products

182495-82-5Relevant articles and documents

Synthesis of (R)-Configured 2′-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides

Schr?der, Arne S.,Kotljarova, Olga,Parsa, Edris,Iwan, Katharina,Raddaoui, Nada,Carell, Thomas

, p. 4368 - 4371 (2016)

Investigation of the function of the new epigenetic bases requires the development of stabilized analogues that are stable during base excision repair (BER). Here we report the synthesis of 2′-(R)-fluorinated versions of the phosphoramidites of 5-methylcy

Probing Synergistic Effects of DNA Methylation and 2′-β-Fluorination on i-Motif Stability

Abou Assi, Hala,Lin, Yu Chen,Serrano, Israel,González, Carlos,Damha, Masad J.

supporting information, p. 471 - 477 (2017/12/15)

The possible role of DNA i-motif structures in telomere biology and in the transcriptional regulation of oncogene promoter regions is supported by several recent studies. Herein we investigate the effect of four cytidine nucleosides (and combinations thereof) on i-motif structure and stability, namely 2′-deoxycytidine (dC), 2′-deoxy-5-methyl-cytidine (5-Me-dC), 2′-deoxy-2′-fluoro-arabinocytidine (2′F-araC), and 2′-deoxy-2′-fluoro-5-methyl-arabinocytidine (5-Me-2′F-araC). The base pair 5-Me-2′F-araC:2′F-araC produced i-motifs with a pH1/2 (“pKa”) value that closely matches physiological pH (7.34±0.3). NMR analysis of the most stable telomeric sequence (HJ-2) at pH 7.0 indicated that the structure is stabilized by hybrid 5-Me-dC:2′F-araC hemiprotonated base pairs and therefore highlights the significance of the interplay between base and sugar modifications on the stability of i-motif structures.

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