182880-62-2

Basic information

• Product Name: 4-Fluoro-5-methyl-2-nitrophenol
• Synonyms: 4-Fluoro-5-methyl-2-nitrophenol;Phenol, 4-fluoro-5-methyl-2-nitro-;2-Fluoro-5-hydroxy-4-nitrotoluene, 5-Fluoro-2-hydroxy-4-methylnitrobenzene
• CAS NO: 182880-62-2
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.13
• Mol File: 182880-62-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Fluoro-5-methyl-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-5-methyl-2-nitrophenol(182880-62-2)
• EPA Substance Registry System: 4-Fluoro-5-methyl-2-nitrophenol(182880-62-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 182880-62-2(Hazardous Substances Data)

Upstream product

• 2338-54-7 4-fluoro-3-methylanisol 
• 452-70-0 4-fluoro-3-methylphenol 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

Photochemical nitration by tetranitromethane. Part 36. Adduct formation in the photochemical reactions of 4-fluoroanisole and 4-fluoro-3-methylanisole

The photolysis of the charge transfer (CT) complex of tetranitromethane and 4-fluoroanisole 2 in dichloromethane at -20 deg C gives the epimeric 1-fluoro-4-methoxy-5-nitro-6-trinitromethylcyclohexa-1,3-dienes 9 and 9, the epimeric 1-fluoro-4-methoxy-3-nitro-6-trinitromethylcyclohexa-1,4-dienes 10 and 12, the epimeric 1-fluoro-4-methoxy-6-nitro-3-trinitromethylcyclohexa-1,4-dienes 11 and 13, a 1-fluoro-6-hydroxy-4-methoxy-3-trinitromethylcyclohexa-1,4-diene 14, together with 4-fluoro-2-trinitromethylanisole 3,4-fluoro-2-nitroanisole 4 and 3-fluoro-6-hydroxy-5-nitrobenzoic acid 15.In acetonitrile at 20 or -20 deg C, only minor amounts of adducts 13 and 14 are formed, together with aromatic compounds 3, 4 and 16.The photolysis of the CT complex of tetranitromethane and 4-fluoro-3-methylanisole 7 in dichloromethane at -20 deg C gives the epimeric 1-fluoro-4-methoxy-6-methyl-6-nitro-3-trinitromethylcyclo-hexa-1,4-dienes 23 and 24, 1-fluoro-4-methoxy-2-methyl-r-5-nitro-c-6-trinitromethylcyclohexa-1,3-diene 25 and predominatly 4-fluoro-5-methyl-2-trinitromethylanisole 19.In acetonitrile a similar reaction of 4-fluoro-3-methylanisole 7 gives only adduct 25, lesser amounts of the trinitromethyl compound 19 and increased amounts of 4-fluoro-5-methyl-2-nitroanisole 22.Photolysis reactions with tetranitromethane of either 2 or 7 in 1,1,1,3,3,3-hexafluoropropan-2-ol are slow and yield the nitroanisoles 4, or 20 and 22, respectively.X-Ray crystal structures are reported for 4-fluoro-5-methyl-2-trinitromethylanisole 19 and 4-fluoro-5-methyl-2-nitroanisole 22.