Synthesis and Substrate Properties of Modified Nucleoside 5′-Triphosphates Mimicking dATP in the Reactions of DNA Synthesis Catalyzed by DNA Polymerases
Several modified nucleoside 5′-triphosphates containing adenine-mimicking pyrimidine derivatives as an aglycone were synthesized. The study of substrate properties of these compounds towards DNA-synthesizing enzymes showed their ability of being incorpora
New Pyrimidine Nucleotides as DATP Mimics: Synthesis and Some Biochemical Properties
Some nucleoside 5'-triphosphates with 4,6-diaminopyridine (5-NO2, 5-NH2 or 5-H) as an adenine mimicking nucleobase were synthesized and evaluated as substrates for several DNA polymerases.
Sharkin, Yuri
p. S171 - S173
(2007/10/03)
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