18323-58-5

Basic information

• Product Name: 4-METHYLUMBELLIFERYL OLEATE
• Synonyms: OLEIC ACID-4-METHYLUMBELLIFERYL ESTER;4-METHYLUMBELLIFERYL OLEATE;4-MU-OLEATE;4-methyl-2-oxo-2H-1-benzopyran-7-yl oleate;4-METHYLUMBELLIFERYL OLEATE, FOR FLUORES CENCE;4-MethylumbelliferylOleateA.R.;(Z)-9-Octadecenoic acid (4-methyl-2-oxo-2H-1-benzopyran-7-yl) ester;(Z)-9-Octadecenoic acid 4-methyl-2-oxo-2H-1-benzopyran-7-yl ester
• CAS NO: 18323-58-5
• Molecular Formula: C₂₈H₄₀O₄
• Molecular Weight: 440.61
• EINECS: 242-210-7
• Product Categories: Substrates;Fluorescent Labels and Indicators;Carbohydrates & Derivatives;Fluorescent Labels & Indicators;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;substrate
• Mol File: 18323-58-5.mol

Chemical Properties

• Melting Point: 37-38 °C(lit.)
• Boiling Point: 471.81°C (rough estimate)
• Flash Point: 281.3℃
• Appearance: /
• Density: 1.023
• Vapor Pressure: 4.53E-13mmHg at 25°C
• Refractive Index: 1.4840 (estimate)
• Storage Temp.: −20°C
• Solubility: 2-methoxyethanol: soluble
• BRN: 4887028
• CAS DataBase Reference: 4-METHYLUMBELLIFERYL OLEATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLUMBELLIFERYL OLEATE(18323-58-5)
• EPA Substance Registry System: 4-METHYLUMBELLIFERYL OLEATE(18323-58-5)

Safety Data

• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 18323-58-5(Hazardous Substances Data)

Usage

Uses

Used in Enzyme Assays:
4-Methylumbelliferyl oleate is used as a substrate for enzyme assays, specifically to determine the activity of non-specific esterases and lipases. It serves as a valuable tool in the continuous monitoring of the hydrolytic activity of carboxylesterases, such as acid and alkaline lipases.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methylumbelliferyl oleate is used as a substrate to evaluate the pancreatic lipase inhibitory activity. This application aids in the development and assessment of potential drugs targeting pancreatic lipase, which can be beneficial in the treatment of obesity and related metabolic disorders.
Used in Research and Diagnostics:
4-Methylumbelliferyl oleate is also utilized in research and diagnostic applications, where it helps in the identification and quantification of lipase activity. This information is crucial for understanding the role of lipases in various biological processes and their potential involvement in disease mechanisms.

InChI:InChI=1/C28H40O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27(29)31-24-19-20-25-23(2)21-28(30)32-26(25)22-24/h10-11,19-22H,3-9,12-18H2,1-2H3/b11-10-

Upstream product

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 112-80-1 cis-Octadecenoic acid 
• 108-46-3 recorcinol 
• 112-77-6 (Z)-9-octadecenoyl chloride 

Downstream Products

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 112-80-1 cis-Octadecenoic acid 

Related news

Study of the hydrolysis of 4-METHYLUMBELLIFERYL OLEATE (cas 18323-58-5) by acid lipase and cholesteryl oleate by acid cholesteryl esterase in human leucocytes, fibroblasts and liver08/20/2019

1.1. The characteristics of acid lipase with 4-methylumbelliferyl oleate as substrate and acid cholesteryl esterase with cholesteryl [1-14C]oleate as substrate were investigated in homogenates of human leucocytes, fibroblasts and liver. The substrates were encapsulated in egg yolk lecithin vesic...detailed

Relevant articles and documents

A new class of pure estrogen alpha receptor antagonists; design, synthesis and in-vitro screening

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