- A practical synthesis of biaryls via a thermal decarboxylative Pd-catalyzed cross-coupling reaction operating at moderate temperature
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The palladium-catalyzed decarboxylative cross-coupling of aminothiophene carboxylate and 1-bromo-4-chlorobenzene to produce 3-amino-2-(4-chlorophenyl) thiophene (2) is described. The cross-coupling proceeds under relatively mild conditions using catalytic Pd(0) and TBAB. Through use of a mixed-solvent system of DMF and NMP, it was possible to operate the cross-coupling system at 80 °C. An assessment of carbon dioxide liberation, which provides insight into the reaction operating parameters, is also discussed.
- Mitchell, David,Coppert, David M.,Moynihan, Humphrey A.,Lorenz, Kurt T.,Kissane, Marie,McNamara, Orla A.,Maguire, Anita R.
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p. 981 - 985
(2011/12/15)
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- AMPA RECEPTOR POTENTIATORS
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The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.
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Page/Page column 4
(2010/11/25)
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- PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS
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The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
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Page/Page column 64
(2008/06/13)
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