cas 184032-60-8, 1-Cyclohexene-1-carboxylic acid, 3-methyl- (9CI)

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Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids
A series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. The antimicrobial activity was evaluated using the broth microdilution method. All acids 1-12 exhibited a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with triethylbenzyl ammonium chloride (TEBA) as catalyst.
Vitnik, Vesna D.,Milenkovi, Marina T.,Dilber, Sanda P.,Vitnik, Zeljko J.,Juranic, Ivan O.
scheme or table
p. 741 - 750
(2012/10/07)

One-step conversion of ketones to conjugated acids using bromoform
Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of ,-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conj
Vitnik,Ivanovic,Vitnik,Orevic,Zizak,Juranic,Juranic
experimental part
p. 1457 - 1471
(2009/09/26)