184042-58-8Relevant articles and documents
Carbon-11 and Fluorine-18 Radiolabeled Pyridopyrazinone Derivatives for Positron Emission Tomography (PET) Imaging of Phosphodiesterase-5 (PDE5)
Chekol, Rufael,Gheysens, Olivier,Ahamed, Muneer,Cleynhens, Jan,Pokreisz, Peter,Vanhoof, Greet,Janssens, Stefan,Verbruggen, Alfons,Bormans, Guy
supporting information, p. 486 - 496 (2017/04/26)
The cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) plays an important role in various pathologies including pulmonary arterial hypertension and cardiomyopathy. PDE5 represents an important therapeutic and/or prognostic targ
HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS
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Paragraph 1097; 1098; 1099; 1100, (2013/08/14)
The present application relates to novel aryl compounds with heterocyclic substituents, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention
GLYCINE COMPOUND
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Page/Page column 23, (2012/07/28)
[Problem] The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. [Means for Solution] The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that a compound of the present invention or a salt thereof exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. The present invention further relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound of the present invention or a salt thereof, and an excipient.
PURINE COMPOUNDS USED AS CB2 AGONISTS
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Page/Page column 16, (2011/10/13)
A compound of the formula (I) and pharmaceutical compositions for the treatment of pain.
PURINE COMPOUNDS
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Page/Page column 10, (2011/10/13)
A compound of the formula: and pharmaceutical compositions for the treatment or prevention of pain.
Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging
Breyholz, Hans-Joerg,Wagner, Stefan,Faust, Andreas,Riemann, Burkhard,Hoeltke, Carsten,Hermann, Sven,Schober, Otmar,Schaefers, Michael,Kopka, Klaus
experimental part, p. 777 - 789 (2011/01/05)
Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endopeptidases. Representing a subfamily of the metzincin superfamily, MMPs are involved in the proteolytic degradation of components of the extracellular matrix. Unregulated MMP expression,
Purine Compounds
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Page/Page column 16-17, (2010/07/04)
A compound of the formula: and pharmaceutical compositions for the treatment of pain.
Imidazopyridine Kinase Inhibitors
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Page/Page column 74; 118, (2009/01/20)
The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
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Page/Page column 90, (2008/06/13)
The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R1, n, R3,Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.
SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS
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Page 81, (2010/11/30)
The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.