- An "on-water" exploration of CuO nanoparticle catalysed synthesis of 2-aminobenzothiazoles
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An "on-water" one-pot process has been engineered for the preparation of 2-aminobenzothiazole from ortho-halo (-F, -Cl, -Br and -I) substituted unsymmetrical thioureas. For ortho -I and -Br substrates the reactions afford 2-aminobenzothiazoles under metal free condition promoted by base. However, the relatively inert ortho -Cl and -F substrates undergo intramolecular arylthiolation only in the presence of CuO nanoparticles yielding 2-aminobenzothiazoles. This methodology provides easy access to aminobenzothiazoles utilising even the ortho -Cl and -F substrates. The catalyst is recyclable several times without loss of substantial activity. Other remarkable features include the wide range of functional group tolerance, absence of chromatographic purification (for ortho -I and -Br substrates) and providing moderate to excellent yield of the products under mild conditions, thus rendering the methodology as a highly eco-friendly alternative to the existing methods.
- Rout, Saroj Kumar,Guin, Srimanta,Nath, Jayashree,Patel, Bhisma K.
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p. 2491 - 2498
(2013/02/21)
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- Synthesis of 2-Arylaminobenzothiazoles and Aryl Isothiocyanates as Antitubercular Agents
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A series of 2-arylaminobenzothiazoles (II) and aryl isothiocyanates (I) bearing a nitro group in the aryl moiety have been synthesized and screened against M. tuberculosis (H37Rv) in vitro.Most of the isothiocyanate derivatives (I) show antitub
- Pande, Anil,Lokhande, S. R.,Patel, Madhuben R.,Khadse, B. G.
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p. 311 - 312
(2007/10/02)
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