Syntheses of the syn and anti α-amino-β-hydroxy acids of vancomycin: (2S, 3R) and (2R, 3R) p-chloro-3-hydroxytyrosines
Syntheses of (2S, 3R) and (2R, 3R) methyl p-chloro-3-hydroxytyrosinates 2 and 3 respectively, have been achieved from 3-chloro-4-hydroxybenzoic acid. These approaches relied on the asymmetric hydrogenation of highly functionalized carbonyl derivatives using chiral ruthenium complexes.
Girard, Anne,Greck, Christine,Ferroud, Didier,Genet, Jean Pierre
p. 7967 - 7970
(2007/10/03)
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