METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE 2-SULFONYLOXY-1-PHENYLETHANOL DERIVATIVES
Optically active 2-sulfonyloxy-1-phenylethanol derivative of formula (II) can be prepared easily and selectively by the method of the present invention using an asymmetric reduction of an α-sulfonyloxy acetophenone compound with a rhodium catalyst having petamethylcyclopentadienyl group and a hydrogen donor, and the compound of formula (II) obtained in the inventive method exhibits a higher e.e. (enantiomer excess) value than that of the products in the conventional methods.
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Page/Page column 21
(2008/12/05)
A METHOD FOR THE PRODUCTION OF CHIRAL SUBSTITUTED EPOXIDES
A method for the production of chiral substituted epoxides of formula (I) wherein R represents a substituted C5-C20-aryl-, C5-C20-heterocycle or C1-C20-alkyl radical, R1 represents H or is
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Page/Page column 16
(2008/06/13)
Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative
There are provided an acetalsulfonate derivative useful as an intermediate for medicines and agricultural chemicals, a process for industrially producing the derivative, and a process for industrially producing a styrene oxide derivative from the acetalsulfonate derivative or from a mandelic acid derivative. A process for producing an acetalsulfonate derivative which comprises a first step of esterifying a mandelic acid derivative to form a mandelic ester derivative, a second step of protecting the mandelic ester derivative by an acetal to form an acetal derivative, a third step of reducing the acetal derivative to form an ethanediol derivative and a fourth step of reacting the ethanediol derivative with a sulfonyl chloride derivative. A process for producing a styrene oxide derivative which comprises a deprotecting step of deacetalizing the acetalsulfonate derivative and a step of epoxidizing the sulfonate derivative obtained in the deprotecting step with the aid of a base catalyst.
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Page/Page column 17
(2010/01/31)
An efficient synthesis of enantiopure 3-chlorostyrene oxide via oxazaborolidine-catalyzed reduction
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Choi, Ok Kyoung,Cho, Byung Tae
p. 493 - 497
(2007/10/03)
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