- Preparation method of 2, 3-dichloro-6-cyanopyridine
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The invention discloses a preparation method of 2, 3-dichloro-6-cyanopyridine, and the method comprises the following steps: by using a metal chloride salt as a catalyst and phosphorus halide as a cocatalyst, carrying out one-step liquid-phase chlorination reaction on raw materials 2-chloro-6-cyanopyridine and chlorine to obtain 2, 3-dichloro-6-cyanopyridine; wherein the metal chloride salt is selected from at least one of WCl6, MoCl5, FeCl3, AlCl3, CuCl2, ZnCl2, RuCl3, SnCl4 and SbCl5, and the cocatalyst is selected from at least one of phosphorus pentachloride, phosphorus trichloride, phosphorus pentabromide and phosphorus tribromide. The method is simple in reaction process, low in production cost and high in target product selectivity and yield, the yield is 90% or above by optimizingreaction conditions, and the method has a good industrial prospect.
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Paragraph 0025-0026; 0043-0065
(2020/05/08)
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