18513-79-6

Basic information

• Product Name: 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
• Synonyms: 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE;TIMTEC-BB SBB004289;1,2,3,6-TetrahydropyridineHCl;1,2,3,6-Tetrahydropyridine hydrochloride 98%
• CAS NO: 18513-79-6
• Molecular Formula: C₅H₉N*ClH
• Molecular Weight: 119.59
• Product Categories: Heterocyclic Compounds;C5;Heterocyclic Building Blocks;Pyridines
• Mol File: 18513-79-6.mol

Chemical Properties

• Melting Point: 189-191 °C(lit.)
• Boiling Point: 161.1oC at 760 mmHg
• Flash Point: 51.2oC
• Appearance: /
• Vapor Pressure: 2.02mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(18513-79-6)
• EPA Substance Registry System: 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(18513-79-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 18513-79-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1,2,3,6-Tetrahydropyridine hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of molecules with diverse therapeutic applications.
Used in Chemical Synthesis:
1,2,3,6-Tetrahydropyridine hydrochloride is used as a heterocyclic building block in chemical synthesis. Its versatile structure enables the development of a variety of chemical compounds with different properties and applications.
Used in the Synthesis of Olefin Metathesis Catalysts:
1,2,3,6-Tetrahydropyridine hydrochloride is used as a crucial component in the synthetic preparation of efficient water-soluble olefin metathesis catalysts. These catalysts play a significant role in the field of polymer chemistry and materials science, as they facilitate the formation of new carbon-carbon double bonds and the rearrangement of existing ones, leading to the creation of novel polymers and materials with unique properties.

InChI:InChI=1/C5H9N.ClH/c1-2-4-6-5-3-1;/h1-2,6H,3-5H2;1H

Upstream product

• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 
• 80662-96-0 N-2-propen-1-yl-3-buten-1-amine 
• 1211531-06-4 N-Boc-(3-butenyl)(allyl)amine 

Downstream Products

• 109270-63-5 (5,6-dihydropyridin-1(2H)-yl)(2-iodophenyl)methanone 
• 100381-46-2 (3,6-dihydro-2H-[1]pyridyl)-phenyl-acetonitrile 

Relevant articles and documents

Highly active water-soluble olefin metathesis catalyst

A novel water-soluble ruthenium olefin metathesis catalyst supported by a poly(ethylene glycol) conjugated saturated 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligand is reported. The catalyst displays improved activity in ring-opening metathesis polymerization, ring-closing metathesis, and cross-metathesis reactions in aqueous media. Copyright

Effect of added salt on ring-closing metathesis catalyzed by a water-soluble hoveyda-grubbs type complex to form N-containing heterocycles in aqueous media

The efficiency of ring-closing metathesis catalyzed by a Hoveyda-Grubbs type catalyst in water can be enhanced by addition of a chloride salt under neutral conditions. UV-vis spectroscopic study showed that a characteristic band of the catalyst around 380 nm remained over 16 h in the presence of KCl, whereas the band distinctly decreased in the absence of KCl. The disappearance of the band is ascribed to a displacement of a chloride ligand by a water molecule or a hydroxide anion. The spectral changes can be related to the metathesis activity. The experimental results indicate that avoidance of the chloride ligand loss is important to maintain the metathesis activity in water.

Water soluble homogeneous catalysts that are recoverable by phase selectivity and host-guest interactions

A chemical reaction is catalyzed in an organic solvent using a water soluble N-heterocyclic carbene homogeneous catalyst to form a reaction mixture. An aqueous phase in the reaction mixture. A solvent in which the catalyst is insoluble is added to the reaction mixture, causing the catalyst to migrate to the aqueous phase to form a catalyst-laden aqueous phase. The catalyst is extracted from the catalyst-laden aqueous phase.

CYCLIN DEPENDENT KINASE INHIBITORS

This invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

Removable Water-Soluble Olefin Metathesis Catalyst via Host-Guest Interaction

A highly removable N-heterocyclic carbene ligand for a transition-metal catalyst in aqueous media via host-guest interactions has been developed. Water-soluble adamantyl tethered ethylene glycol in the ligand leads a hydrophobic inclusion into the cavity of β-cyclodextrin. Ruthenium (Ru) olefin metathesis catalyst with this ligand demonstrated excellent performance in various metathesis reactions in water as well as in CH2Cl2, and removal of residual Ru was performed via filtration utilizing a host-guest interaction and extraction.

A simple and practical preparation of an efficient water soluble olefin metathesis catalyst

This study details homogeneous olefin metathesis in water catalysed by a di-ammonium functionalised Ru-alkylidene complex. A facile gram scale synthesis of an air stable catalyst precursor which can be readily converted to its water soluble derivative is described. The di-ammonium functionalised Ru-alkylidene complex facilitates a range of ring-closing metathesis (RCM) and cross-metathesis (CM) reactions in water.

Divergent Approach to a Family of Tyrosine-Derived Ru-Alkylidene Olefin Metathesis Catalysts

A simple and generic approach to access a new family of Ru-alkylidene olefin metathesis catalysts with specialized properties is reported. This strategy utilizes a late stage, utilitarian Hoveyda-type ligand derived from tyrosine, which can be accessed via a multigram-scale synthesis. Further functionalization allows the catalyst properties to be tuned, giving access to modified second-generation Hoveyda-Grubbs-type catalysts. This divergent synthetic approach can be used to access solid-supported catalysts and catalysts that function under solvent-free and aqueous conditions.

Small-molecule N-heterocyclic-carbene-containing olefin-metathesis catalysts for use in water

(Chemical Equation Presented) ROMPing around in water: Two well-defined, small-molecule olefin-metathesis catalysts (1 and 2) are introduced. While they are insufficiently stable to mediate most cross-metathesis reactions in water, these catalysts competently mediate ring-opening metathesis polymerization (ROMP) and ring-closing metathesis reactions in an aqueous environment.