185315-53-1

Basic information

• Product Name: Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
• Synonyms: Pyridine, 3-chloro-2-(chloromethyl)- (9CI);3-chloro-pyridin-2-ylMethyl chloride;3-Chloro-2-(chloroMethyl)pyridine
• CAS NO: 185315-53-1
• Molecular Formula: C₆H₅Cl₂N
• Molecular Weight: 162.0166
• Product Categories: HALIDE
• Mol File: 185315-53-1.mol

Chemical Properties

• Boiling Point: 213.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.324±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.43±0.22(Predicted)
• CAS DataBase Reference: Pyridine, 3-chloro-2-(chloromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-chloro-2-(chloromethyl)- (9CI)(185315-53-1)
• EPA Substance Registry System: Pyridine, 3-chloro-2-(chloromethyl)- (9CI)(185315-53-1)

Safety Data

• Hazardous Substances Data: 185315-53-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine, 3-chloro-2-(chloromethyl)(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, Pyridine, 3-chloro-2-(chloromethyl)(9CI) serves as an essential intermediate for the production of various agrochemicals. Its reactivity and functional groups make it suitable for the synthesis of compounds with pesticidal, herbicidal, or other agricultural applications.
Used in Industrial Chemicals Production:
Pyridine, 3-chloro-2-(chloromethyl)(9CI) is also utilized in the manufacturing of other industrial chemicals. Its properties and reactivity contribute to the development of specialty chemicals used in various industries, such as dyes, plastics, and coatings.

Upstream product

• 60588-81-0 3-chloro-2-hydroxy-methyl-pyridine 
• 52313-57-2 3-Chlor-2-picolin-1-oxid 
• 124425-86-1 Acetic acid 3-chloro-pyridin-2-ylmethyl ester 

Relevant articles and documents

ANTIMICROBIAL AGENTS AND SCREENING METHODS

Disclosed herein are antibacterial and antimicrobial compositions and methods of use. Also disclosed are screening assays for identification of an agent that specifically inhibits DsbB or bVKOR. Such methods are useful, for example, in identifying antibacterial and antimicrobial agents and compositions.

2--1H-thienoimidazoles. A Novel Class of Gastric H+/K+-ATPase Inhibitors

2-thienoimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase.The isomers of the two possible thienoimidazole series were found to be potent inhibitors of gastric acid secretion in vitro and in vivo.Structure-activity relationships indicate that especially lipophilic alkoxy, benzyloxy, and phenoxy substituents with additional electron-demanding properties in the 4-position of the pyridine moiety combined with an unsubstituted thienoimidazole lead to highly active compounds with a favorable chemical stability.Various substitution patterns in the thienoimidazole moiety result in lower biological activity.The heptafluorobutyloxy derivative saviprazole (HOE 731, 5d) was selected for further development and is currently undergoing clinical evaluation.Comprehensive pharmacological studies indicate a pharmacodynamic profile different to omeprazole, the first H+/K+-ATPase blocker introduced on the market.

IMIDAZOLYLMETHYLTHIOETHYL DITHIOCARBAMATE COMPOUNDS

The compounds are dithiocarbamates and isothioureas which are histamine H 2-antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea.