New Chiral Dichlorophosphines and Their Use in the Synthesis of Phosphetane Oxides and Phosphinic Chlorides
Myrtanyl-, bornyl- and isopinocampheyldichlorophosphines have been prepared from the corresponding alkyl chlorides via diastereospecific reactions of the Grignard reagents with PCl3 or (Et2N)2-PCl. Two applications of these compounds to synthetic asymmetric organophosphorus chemistry have been examined: their reactions with 2,3,3-trimethylbutene and AlCl3 afford either P-chiral phosphetane oxides or, in the presence of gaseous HCl, P-chiral phosphinic chlorides with moderate to high diastereoselectivity.
Marinetti, Angela,Buzin, Francois-Xavier,Ricard, Louis