- Development of a new synthesis approach for S-pregabalin by optimizing the preparation stages
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In the present study, we aimed to optimize the synthesis stages of S-pregabalin ((S)-3-(aminomethyl)-5-methylhexanoic acid), a well-known anticonvulsant drug. We used appropriate solvents and compounds to reach a straightforward and applicable method. The advantages of this research were avoiding use of expensive and environment pollutant reagents and solvents, and also using a recoverable reagent. Discarding prevention of the intermediates and reagents besides attaining a higher yield of the obtained product were the additional achievements. All structures were characterized by FT-IR, 1H NMR, and the purity of S-pregabalin was evaluated using the HPLC assay.
- Mansoori, Arsalan,Zahednezhad, Fahimeh,Bavili Tabrizi, Ahad,Shahbazi Mojarrad, Javid
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- PROCESS FOR PREPARING PREGABALIN AND ITS INTERMEDIATE
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Processes for preparing pregabalin and its intermediate such as 3-(carbamoylmethyl)-5-methylhexanoic acid are provided. The process for preparing pregabalin mainly comprises reacting 3-(carbamoylmethyl)-5-methylhexanoic acid with (+)-phenyl ethyl amine, followed by reacting with bromine in the presence of base to obtain pregabalin.
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