Enzymatic preparation of an optically active precursor of the CC-1065/duocarmycin pharmacophore
Acetylation of 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol with vinyl acetate in the presence of porcine pancreatic lipase gave the (R)-mono-acetate (ee = 92%). The (S)-mono-acetate was obtained via acetylation of the diol followed by transesterificat
Chenevert, Robert,Courchesne, Gabriel
p. 11 - 12
(2007/10/03)
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