186268-78-0

Basic information

• Product Name: (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID
• Synonyms: (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID;(2S)-1-(3,3-Dimethyl-2-oxopentanoyl)-pyrrolidine-2-carboxylic acid
• CAS NO: 186268-78-0
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.28
• Product Categories: Prolines
• Mol File: 186268-78-0.mol

Chemical Properties

• Boiling Point: 386.198 °C at 760 mmHg
• Flash Point: 187.366 °C
• Appearance: /
• Density: 1.189 g/cm³
• CAS DataBase Reference: (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID(186268-78-0)
• EPA Substance Registry System: (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID(186268-78-0)

Safety Data

• Hazardous Substances Data: 186268-78-0(Hazardous Substances Data)

Usage

Uses

Given the provided materials, there are no explicit uses mentioned for (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID. However, based on its complex structure, it can be inferred that it may have potential applications in various fields such as pharmaceuticals, chemical research, or material science, pending further investigation and validation. If additional information or context is provided, the uses could be listed as follows:
Used in Pharmaceutical Industry:
(2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID could be used as a [specific application type] for [reason related to its chemical properties or potential therapeutic effects], pending further research and clinical trials.
Used in Chemical Research:
In the field of chemical research, (2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID might serve as a [specific application type], such as a reagent or a component in the synthesis of other compounds, due to its unique structural features.

Upstream product

• 186268-77-9 methyl (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylate 
• 139419-63-9 methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate 
• 28276-08-6 1,1-dimethylpropylmagnesium chloride 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 1233885-04-5 C₁₄H₂₃NO₄ 

Downstream Products

• 215169-04-3 (S)-1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-carboxylic acid (R)-1-(3-tert-butoxycarbonylmethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propyl ester 
• 320608-01-3 C₂₄H₃₅N₃O₇ 
• 320608-90-0 C₂₅H₃₄N₄O₆ 
• 320608-26-2 C₁₈H₂₄N₄O₄ 
• 320608-32-0 C₁₈H₂₄N₄O₄ 
• 186452-09-5 3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate 

Relevant articles and documents

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders. Rapamycin and FK506 are two macrocyclic natural products that bind to these proteins indiscriminately but with nanomolar affinity. We here report the cocrystal structure of FKBP51 with a simplified α-ketoamide analogue derived from FK506 and the first structure-activity relationship analysis for FKBP51 and FKBP52 based on this compound. In particular, the tert-pentyl group of this ligand was systematically replaced by a cyclohexyl ring system, which more closely resembles the pyranose ring in the high-affinity ligands rapamycin and FK506. The interaction with FKBPs was found to be surprisingly tolerant to the stereochemistry of the attached cyclohexyl substituents. The molecular basis for this tolerance was elucidated by X-ray cocrystallography.

N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked sulfonamides of heterocyclic thioesters.

Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders

This invention relates to novel compositions and uses of N-heterocyclic carboxylic acids and carboxylic acid isosteres for treating a vision disorder, improving vision, treating memory impairment or enhancing memory performance in an animal.

HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES

This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic thioesters and ketones.

Method for treating nerve injury caused as a result of surgery

The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.

N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders

The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance.

Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects

The recent discovery that small molecule ligands for the peptidyl-prolyl isomerase (PPIase) FKBP12 possess powerful neuroprotective and neuroregenerative properties in vitro and in vivo suggests therapeutic utility for such compounds in neurodegenerative disease. The neurotrophic effects of these compounds are independent of the immunosuppressive pathways by which drugs such as FK506 and rapamycin operate. Previous work by ourselves and other groups exploring the structure-activity relationships (SAR) of small molecules that mimic only the FKBP binding domain portion of FK506 has focused on esters of proline and pipecolic acid. We have explored amide and thioester analogues of these earlier structures and found that they too are extremely potent in promoting recovery of lesioned dopaminergic pathways in a mouse model of Parkinson's disease. Several compounds were shown to be highly effective upon oral administration after lesioning of the dopaminergic pathway, providing further evidence of the potential clinical utility of a variety of structural classes of FKBP12 ligands.

Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal, using pipecolic acid derivatives.

N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses

This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.