- New carbocyclic nucleosides: Synthesis of carbocyclic pseudoisocytidine and its analogs
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Cyclopentane-containing nucleoside analogs with a CC connection between the (heterocyclic) base and the carbocyclic scaffold are quite rare. Herein, we report the synthesis of previously unknown racemic carbocyclic pseudoisocytidine and its analogs, which
- Maier, Luká?,Hylse, Ond?ej,Ne?as, Marek,Trbu?ek, Martin,Ytre-Arne, Mari,Dalhus, Bj?rn,Bjor?s, Magnar,Paruch, Kamil
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supporting information
p. 3713 - 3716
(2014/06/23)
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- Chemoselective synthesis of unsymmetrical internal alkynes or vinyl sulfones via palladium-catalyzed cross-coupling reaction of sodium sulfinates with alkynes
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A highly efficient and mild palladium-catalyzed cross-coupling of sodium sulfinates and alkynes for the selective synthesis of unsymmetrical internal alkynes and vinyl sulfones has been developed. This methodology has advantages of easily accessible starting materials, functional group tolerance and a wide range of substrates, which provides rapid access to alkynes and vinyl sulfones.
- Xu, Yanli,Zhao, Jinwu,Tang, Xiaodong,Wu, Wanqing,Jiang, Huanfeng
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p. 2029 - 2039
(2014/07/07)
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- Stereoselective synthesis of substituted arylsulfonylated 1,3-butadienes and 2-propenoates by sulfonylation of acetylenic ester
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Protonation of the reactive intermediates produced in the reaction between sodium arylsulfinates and two equiv. of dialkyl acetylenedicarboxylates in DMF, by H2O lead to substituted (1E,3E)-1-(arylsulfonyl)-1,3-butadiene-1,2,3,4- tetracarboxylates in moderate yields. A regioselective method for the synthesis of alkyl (E)-3-(arylsulfonyl)-2-propenoates is described. These reactions provide a useful synthetic route to highly functionalized 1,3-butadienes and 2-propenoates.
- Khalili, Gholamhossein
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p. 532 - 538
(2013/10/21)
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- The phenylsulfonyl group as a temporal regiochemical controller in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides
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(Chemical Equation Presented) Controlling the regioselectivity: The phenylsulfonyl group controlled the regioselectivity in the title reaction to afford pyrrolidine-2,3-dicarboxylates with good regioselectivity and high exo selectivity and enantioselectivity (see scheme). The products are precursors to substituted pyrrolidines and pyrrolines that are not attainable by direct 1,3-dipolar cycloadditions with typical acrylates.
- Lopez-Perez, Ana,Adrio, Javier,Carretero, Juan C.
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supporting information; experimental part
p. 340 - 343
(2009/04/14)
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- An economical and convenient synthesis of vinyl sulfones
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A general process for the efficient synthesis of vinyl sulfones has been developed using commercially available sulfinic acid sodium salts and dibromides. A variety of phenyl and methyl vinyl sulfones have been formed in good yields, in the absence of any catalyst. Georg Thieme Verlag Stuttgart.
- Guan, Zheng-Hui,Zuo, Wei,Zhao, Lian-Biao,Ren, Zhi-Hui,Liang, Yong-Min
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p. 1465 - 1470
(2008/02/05)
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- Facile method for solid-phase synthesis of vinyl sulfones using polystyrene-supported selenomethyl aryl sulfone
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Treatment of novel polystyrene-supported selenomethyl aryl sulfone with LDA followed by alkylation and oxidation elimination efficiently afforded vinyl sulfones in good yields and purities.
- Sheng, Shou-Ri,Zhou, Wei,Zhong, Ming-Hua,Liu, Xiao-Ling,Chen, Hui-Zong
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p. 815 - 821
(2007/10/03)
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- Polystyrene-Supported α-Seleno Carbanions: Efficient Reagents for Highly Stereocontrolled Syntheses of Vinylphosphonates and Vinylsulfones
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Polystyrene-supported selenomethyl-phosphonate and polystyrene-supported selenomethyl-sulfonates have been prepared. These novel reagents were treated with LDA (or n-BuLi) to produce polystyrene-supported α-seleno carbanions, which reacted with alkyl halides, followed by stereospecific selenoxide syn-elimination to give E-vinylphosphonates and E-vinylsulfones respectively. And also these novel polymer reagents can be regenerated and reused.
- Xu, Wei Ming,Tang, E,Huang, Xian
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p. 2094 - 2098
(2007/10/03)
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- Polystyrene-supported selenosulfonates: Efficient reagents for regio- and stereocontrolled synthesis of vinyl sulfones
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Two novel polystyrene-supported selenosulfonates reagents have been developed. As reagents for boron trifluoride catalyzed or AIBN catalyzed addition to olefins were successfully demonstrated and have been used for regioselective synthesis of vinyl sulfon
- Qian,Huang
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p. 1913 - 1916
(2007/10/03)
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- Pharmaceutical compositions containing acrylic acid derivatives and their use in the medicine
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Known acrylic acid derivatives of formula wherein, n is an integer of from 0 to 2,R represents a hydrogen, an alkaline or an alkaline earth metal atom, or a C1 4alkyl-group, and, R1 represents a hydrogen or a halogen atom or a C
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- Regiochemical Control of the Diels-Alder Reactions with β-Phenylsulphonylacrylate Esters
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Alkyl α-phenylsulphonylacrylates have been made as geometrically pure isomers; the Z-isomer reacts with dienes in Diels-Alder cycloadditions to afford the oposite regiochemistry to that observed with the E-isomer and this provides a useful method for reversing normal carbonyl directing effects.
- Buss, Antony D.,Hirst, Gavin C.,Parsons, Philip J.
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p. 1836 - 1837
(2007/10/02)
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- STEREOSPECIFIC VINYL SUBSTITUTIONS OCCURRING BY FREE RADICAL ADDITION-ELIMINATION
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The free radical chain reaction between cyclohexyl-HgCl and (E) or (Z) MeO2CCH=CHSnBu3, MeO2CCH=CHI, or ClCH=CHHgCl forms MeO2CCH=CHC6H11 or ClCH=CHC6H11 in a stereospecific manner with retention of stereochemistry.
- Russell, Glen A.,Ngowiwatchai, Preecha
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p. 4975 - 4978
(2007/10/02)
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- The Arenesulphonomercuriation of Alkenes - a Route to Vinyl Sulphones
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Vinyl sulphones were obtained from the reaction of alkenes with mercury(II) chloride and sodium arenesulphinate followed by base catalysed eliminative demercuriation.
- Sas, Wojciech
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p. 862 - 863
(2007/10/02)
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