Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor
A versatile and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the aromatic ring. Whereas hydrolases were not suitable for resoluti
A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction
A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.
Kang, Soon Bang,Ahn, Eu Jin,Kim, Youseung,Kim, Yong Hae
p. 9317 - 9320
(2007/10/03)
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