An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques
An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CLpro).
Diffley, John F. X.,Joshi, Dhira,Milligan, Jennifer C.,O'Reilly, Nicola,Papageorgiou, George,Zeisner, Theresa U.
p. 20457 - 20464
(2021/06/26)
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