- CERTAIN CHEMICAL COMPOSITIONS AND METHODS OF USE THEREOF
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The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or diso
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Paragraph 0163-0164
(2021/11/20)
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- From tetrazoles via hydrazonoyl chlorides to 1,3,4-thiadiazole oligomers
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5-Substituted tetrazoles react rapidly with Appel salt 1 at room temperature to give hydrazonoyl chlorides (14) in high yield. 5-Aminotetrazole reacts further to give an extended bis-imine (6) which, with triphenylphosphine at room temperature, rapidly gives 1,3,4-thiadiazoles 15 and 17. The mono-imines 14 react similarly to give simpler thiadiazoles 18 in high yield. By repetition of the tetrazole formation and Appel salt-triphenylphosphine sequence, these 2-cyanothiadiazoles 18 are converted in high yield into thiadiazole dimers and trimers 21, n = 1 and 2. These reactions are explained mechanistically. (C) 2000 Elsevier Science Ltd.
- Le,Rees,Sivadasan
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p. 9407 - 9411
(2007/10/03)
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- A New Method for the Preparation of Tetrazoles From Nitriles Using Trimethylsilylazide/Trimethylaluminum
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Tetrazoles are prepared in good yields from alkyl and aryl nitriles by treatment with equimolar trimethylaluminum and trimethylsilylazide.Yields, substrate compatibility, and reaction temperature are comparable with the use of other metal azides such as A
- Huff, Bret E.,Staszak, Michael A.
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p. 8011 - 8014
(2007/10/02)
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- 4-Me-1-(2-(1H-tetrazol-5-yl)ethyl)benzene sulfonate and N-2-(1H-tetrazol-5-yl)ethyl methanesulfonamide
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At least one compound defined by one of the following formulae: STR1 where X represents Cl, Br, STR2 or--SCH3, and n is 1 or 2; and have been administered to animals to improve the efficiency of food utilization by these animals. These compounds can be administered orally by combining the compounds with feed compositions and fed to animals such as ruminants with a developed rumen function as well as other animals that ferment fibrous material and vegetable matter in the cecum or colon. These compounds effect the rumen metabolism to increase the production of propionate relative to other volatile fatty acids, particularly acetate and to inhibit methanogenesis.
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