187804-79-1

Basic information

• Product Name: 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID
• Synonyms: 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID;[3-FLUORO-4-(TRIFLUOROMETHOXY)PHENYL]BORONIC ACID
• CAS NO: 187804-79-1
• Molecular Formula: C7H5BF4O3
• Molecular Weight: 223.92
• Mol File: 187804-79-1.mol

Chemical Properties

• Melting Point: 141-143 °C
• Boiling Point: 267.1 °C at 760 mmHg
• Flash Point: 115.4 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 0.00412mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 7.21±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID(187804-79-1)
• EPA Substance Registry System: 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID(187804-79-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 187804-79-1(Hazardous Substances Data)

Usage

Uses

3-Fluoro-4-(trifluoromethoxy)phenylboronic acid

InChI:InChI=1/C7H5BF4O3/c9-5-3-4(8(13)14)1-2-6(5)15-7(10,11)12/h1-3,13-14H

Upstream product

• 105529-58-6 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene 
• 121-43-7 Trimethyl borate 

Downstream Products

• 1599467-66-9 4-(4-bromophenoxy)-2-fluoro-1-(trifluoromethoxy)benzene 
• 1599467-70-5 2-(4-(3-fluoro-4-(trifluoromethoxy)phenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1599467-76-1 6-chloro-4-ethoxy-3-(4-(3-fluoro-4-(trifluoromethoxy)phenoxy)phenyl)-7-methoxy-2-methylquinoline 
• 1354745-81-5 6-chloro-3-(4-(3-fluoro-4-(trifluoromethoxy)phenoxy)-phenyl)-7-methoxy-2-methylquinolin-4(1H)-one 
• 1262619-21-5 6-[3-fluoro-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824)

New heterocyclic analogues of the potent biphenyl class derived from antitubercular drug PA-824 were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both phenyl

PENTACYCLIC LIQUID CRYSTAL COMPOUND HAVING CF2O BONDING GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY

The invention provides a five-ring liquid crystal compound having a CF2O bonding group as a new compound having a general physical properties necessary for compounds, stability to heat, light and so forth, a wide temperature range of liquid cry

INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), Wherein X1 , R1 , R2 , R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

Pyrazole derivatives, compositions containing such compounds and methods of use

Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.