18807-74-4

Basic information

• Product Name: N-CARBOBENZOXY-1,5-DIAMINOPENTANE HYDROCHLORIDE
• Synonyms: BENZYL N-(5-AMINOAMYL)CARBAMATE HYDROCHLORIDE;BENZYL N-(5-AMINOPENTYL)CARBAMATE HYDROCHLORIDE;N-CBZ-1,5-DIAMINOPENTANE HYDROCHLORIDE;N-CBZ-DIAMINOPENTANE HYDROCHLORIDE;N-DIAMINOPENTANE HCL;N-Z-1,5-DIAMINOPENTANE HYDROCHLORIDE;N-(5-AMINOAMYL)CARBAMIC ACID BENZYL ESTER HYDROCHLORIDE;N-(5-AMINOPENTYL)CARBAMIC ACID BENZYL ESTER HYDROCHLORIDE
• CAS NO: 18807-74-4
• Molecular Formula: C₁₃H₂₀N₂O₂*ClH
• Molecular Weight: 272.77
• Product Categories: Monoprotected Diaminoalkanes;N-Cbz-diaminoalkanes
• Mol File: 18807-74-4.mol

Chemical Properties

• Melting Point: 172-175 °C
• Boiling Point: 424.7°C at 760 mmHg
• Flash Point: 210.7°C
• Appearance: /
• Vapor Pressure: 1.28E-07mmHg at 25°C
• Storage Temp.: Store at 0°C
• BRN: 3737595
• CAS DataBase Reference: N-CARBOBENZOXY-1,5-DIAMINOPENTANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CARBOBENZOXY-1,5-DIAMINOPENTANE HYDROCHLORIDE(18807-74-4)
• EPA Substance Registry System: N-CARBOBENZOXY-1,5-DIAMINOPENTANE HYDROCHLORIDE(18807-74-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 18807-74-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Introduction of a pentamethylene linker

InChI:InChI=1/C13H20N2O2.ClH/c14-9-5-2-6-10-15-13(16)17-11-12-7-3-1-4-8-12;/h1,3-4,7-8H,2,5-6,9-11,14H2,(H,15,16);1H

Upstream product

• 18807-70-0 N,N'-pentane-1,5-diyl-bis-carbamic acid dibenzyl ester 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 462-94-2 1,5-diaminopentane 
• 315203-49-7 1-azidopentane-5-(N-benzyloxycarbonyl)amine 
• 111-24-0 1,5-dibromo-pentane 
• 17607-21-5 1,5-diazidopentane 
• 148759-41-5 1-azido-5-aminopentane 

Downstream Products

• 89450-67-9 N-<2-(1-uracilyl)ethyl>-N'-carbobenzoxypentamethylenediamine hydrobromide 
• 89450-71-5 N-<3-(1-uracilyl)propyl>-N'-carbobenzoxypentamethylenediamine hydrobromide 
• 205874-85-7 N¹-benzyloxycarbonyl-N⁵-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)-1,5-pentanediamine 
• 205874-97-1 N¹-benzyloxycarbonyl-N⁵-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)-1,5-pentanediamine 
• 1373164-21-6 C₂₀H₃₃N₃O₄ 
• 1373164-22-7 C₂₂H₃₂F₃N₃O₅ 
• 1373164-23-8 benzyl 5-(N-(2-aminoethyl)-2,2,2-trifluoroacetamido)pentylcarbamate 

Relevant articles and documents

An efficient and practical method for the synthesis of mono-N-protected α,ω-diaminoalkanes

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) α,ω-diaminoalkanes (the number of carbon atoms=3, 4, 5 and 6) are accomplished in 81-94% yield by the protection of amine and subsequent reduction of an azido group from α,ω-azido alkyl amines. α,ω-Azido alkyl amines are prepared efficiently by the partial reduction of α,ω-diazidoalkanes which are obtained from the corresponding dibromoalkanes.

Design and synthesis of peptides passing through the blood-brain barrier

The blood-brain barrier (BBB) is a highly selective membranous barrier regulating the transport of substances in blood into the brain parenchyma. At present, delivery of biologically active peptides or peptide drugs into the brain is quite an important subject from the standpoint of chemotherapy for brain diseases H-MeTyr-Arg-MeArg-D-Leu-NH(CH2)8NH2 termed 001-C8 was first synthesized to elucidate the structural specificity of peptides for passing through the BBB. The Na-methylamino acid and D-amino acid residues were appropriately situated in this peptide to protect against the digestion by peptidase. Furthermore, a number of basic peptides were prepared as 001-C8 analogs for studying the relationship between structure and BBB permeability of peptides.

SYNTHESIS OF N-(1-URACILYLALKYL)POLYMETHYLENEDIAMINES

The alkylation of polymethylenediamines with 2-(1-uracilyl)ethyl bromide and 3-(1-uracilyl)propyl bromide yields the corresponding N-(1-uracilylalkyl)polymethylendiamines.