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5-Fluoro-2-methoxyphenylmagnesium bromide is an organometallic compound that features a magnesium atom connected to a phenyl ring, which is substituted with both a methoxy group and a fluorine atom. 5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE plays a significant role in organic synthesis, particularly in Grignard reactions, where it is utilized to incorporate the 5-fluoro-2-methoxyphenyl group into various organic molecules. Its applications are crucial in the manufacturing of pharmaceuticals and the synthesis of other fine chemicals. Moreover, it is also employed in cross-coupling reactions to create carbon-carbon bonds, facilitating the production of intricate organic compounds.

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  • 188132-02-7 Structure
  • Basic information

    1. Product Name: 5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE
    2. Synonyms: 3-FLUORO-6-METHOXYPHENYLMAGNESIUM BROMIDE;5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE;3-FLUORO-6-METHOXYPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;3-fluoro-6-methoxyphenylmagnesium bromide solution;5-fluoro-2-methoxyphenylmagnesium bromide solution;5-Fluoro-2-methoxyphenylmagnesium bromide solution 0.5 in THF;5-Fluoro-2-methoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal;5-Fluoro-2-MethoxyphenylMagnesiuM broMide, 0.5 M solution in THF, SpcSeal
    3. CAS NO:188132-02-7
    4. Molecular Formula: C7H6BrFMgO
    5. Molecular Weight: 229.33
    6. EINECS: N/A
    7. Product Categories: Grignard Reagent
    8. Mol File: 188132-02-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 65 °C
    3. Flash Point: 1 °F
    4. Appearance: Clear yellow to brown/Solution
    5. Density: 0.948 g/mL at 25 °C
    6. Vapor Pressure: 3.51mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE(188132-02-7)
    12. EPA Substance Registry System: 5-FLUORO-2-METHOXYPHENYLMAGNESIUM BROMIDE(188132-02-7)
  • Safety Data

    1. Hazard Codes: F,C,Xn
    2. Statements: 11-14/15-19-34-40-36/37
    3. Safety Statements: 16-26-33-36/37/39-43-45-36/37
    4. RIDADR: UN 2924 3/PG 2
    5. WGK Germany: 1
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 188132-02-7(Hazardous Substances Data)

188132-02-7 Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-methoxyphenylmagnesium bromide is used as a reagent in the synthesis of pharmaceuticals for its ability to introduce the 5-fluoro-2-methoxyphenyl group into organic molecules. This group is often found in the structure of various drug molecules, contributing to their therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Fluoro-2-methoxyphenylmagnesium bromide is used as a Grignard reagent to facilitate the formation of carbon-carbon bonds through Grignard reactions. This is essential for the construction of complex organic molecules and the synthesis of fine chemicals.
Used in Cross-Coupling Reactions:
5-Fluoro-2-methoxyphenylmagnesium bromide is also utilized in cross-coupling reactions as a reagent to form carbon-carbon bonds. This application is vital for the production of complex organic compounds that are used in various chemical and pharmaceutical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 188132-02-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,1,3 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 188132-02:
(8*1)+(7*8)+(6*8)+(5*1)+(4*3)+(3*2)+(2*0)+(1*2)=137
137 % 10 = 7
So 188132-02-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6FO.BrH.Mg/c1-9-7-4-2-6(8)3-5-7;;/h2-4H,1H3;1H;/q-1;;+2/p-1

188132-02-7 Well-known Company Product Price

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  • CAS number
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  • Aldrich

  • (561983)  5-Fluoro-2-methoxyphenylmagnesiumbromidesolution  0.5 M in THF

  • 188132-02-7

  • 561983-50ML

  • 2,102.49CNY

  • Detail

188132-02-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name magnesium,1-fluoro-4-methoxybenzene-5-ide,bromide

1.2 Other means of identification

Product number -
Other names 5-Fluoro-2-methoxyphenylmagnesium bromide solution

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:188132-02-7 SDS

188132-02-7Relevant articles and documents

NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

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Page/Page column 25-26, (2008/06/13)

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, p, X, Y, R3, R4, t and, R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

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