ATP-sensitive potassium channel openers: Synthesis and antihypertensive activity of 4-bicycloxybenzopyrans
Synthesis and hypotensive activity of trans-3,4-dihydro-3-hydroxy-4-[(5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2 -yl)oxy]-2H-1-benzopyrans and their congeners are described. Compounds (-)-9eB and (-)-20B were highly potent ATP-sensitive potassium channel openers.