189011-04-9Relevant articles and documents
QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS
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Page/Page column 16-17, (2010/01/31)
The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by T
Synthetic Study Directed Toward Novel Multi-Linked Heterocycles
Somei, Masanori,Yamada, Yoshikazu,Kitagawa, Keiichi,Sugaya, Katsuko,Tomita, Yayoi,et. al
, p. 434 - 438 (2007/10/03)
2-Amino-4-(1-methylindol-3-yl)thiazole (11c) has a characteristic nucleophilic nature at the 5-position and add to the 4-position of acetylpyridinium acetate (13) producing 2-acetylamino-5-(1-acetyl-1,4-dihydropyridin-4-yl)-4-(1-methylindol-3-yl)-thiazole (1c).Its structure was established by X-ray single crystallographic analysis.Applying the results, simple syntheses of the related tris- (1a-b and 2-8) and tetrakislinked heterocycles (9) were achieved.