Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors
A series of 6-aryl-4,5-heterocyclic-fused pyridazinones were designed and synthesized as selective phosphodiesterase (PDE) IV inhibitors. Biological evaluation of these compounds demonstrated a good selectivity profile toward the PDE IV family and greatly
Dal Piaz, Vittorio,Giovannoni, Maria Paola,Castellana, Carla,Palacios, José Maria,Beleta, Jorge,Doménech, Teresa,Segarra, Victor
p. 1417 - 1421
(2007/10/03)
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