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CAS

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18939-54-3

2-(aziridin-1-yl)ethanethiol, with the chemical formula C4H9NS, is a clear, colorless liquid characterized by a strong, unpleasant odor. It functions as an alkylating agent, capable of interacting with nucleophilic functional groups such as sulfhydryl and amine groups present in proteins and DNA. This interaction can result in DNA damage and cell death, making it a candidate for use in cancer treatment.

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  • 18939-54-3 Structure

  • Basic information

    1. Product Name: 2-(aziridin-1-yl)ethanethiol
    2. Synonyms: 1-aziridineethanethiol; 2-(Aziridin-1-yl)ethanethiol; N-(2-Mercaptoethyl)aziridine
    3. CAS NO:18939-54-3
    4. Molecular Formula: C4H9NS
    5. Molecular Weight: 103.186
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 18939-54-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 151.8°C at 760 mmHg
    3. Flash Point: 45.6°C
    4. Appearance: N/A
    5. Density: 1.075g/cm3
    6. Vapor Pressure: 3.61mmHg at 25°C
    7. Refractive Index: 1.538
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(aziridin-1-yl)ethanethiol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(aziridin-1-yl)ethanethiol(18939-54-3)
    12. EPA Substance Registry System: 2-(aziridin-1-yl)ethanethiol(18939-54-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18939-54-3(Hazardous Substances Data)

18939-54-3 Usage

Uses

Used in Pharmaceutical Industry:
2-(aziridin-1-yl)ethanethiol is used as a chemotherapeutic agent for the treatment of cancer. It has been particularly effective in the form of the prodrug compound Thiotepa, which is utilized to combat various types of cancer. However, due to its high toxicity and the potential for adverse side effects, the application of 2-(aziridin-1-yl)ethanethiol has been restricted, and the development of alternative treatments is ongoing.
Used in Research and Development:
In the scientific community, 2-(aziridin-1-yl)ethanethiol serves as a valuable tool in research for understanding the mechanisms of alkylation and its effects on biological molecules. It aids in the study of DNA repair mechanisms and the development of new therapeutic strategies to counteract the damaging effects of alkylating agents.
It is crucial to handle 2-(aziridin-1-yl)ethanethiol with extreme caution due to its hazardous properties, ensuring safety protocols are strictly followed to mitigate risks associated with its use.

Check Digit Verification of cas no

The CAS Registry Mumber 18939-54-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,3 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18939-54:
(7*1)+(6*8)+(5*9)+(4*3)+(3*9)+(2*5)+(1*4)=153
153 % 10 = 3
So 18939-54-3 is a valid CAS Registry Number.

18939-54-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(aziridin-1-yl)ethanethiol

1.2 Other means of identification

Product number -
Other names 1-Aziridineethanethiol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18939-54-3 SDS

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