cas 18967-42-5, 3,4-DICHLOROBENZYL ISOTHIOCYANATE | Articles data ｜lookchem

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18967-42-5

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Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines
2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.
Hirashima, Akinori,Yoshii, Yutaka,Eto, Morifusa
p. 1062 - 1065
(2007/10/02)

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Chemical Properties

Melting Point: 26-28°C
Boiling Point: 130°C 1mm
Flash Point:142.7°C
Density: 1.32g/cm³
Vapor Pressure: 0.000978mmHg at 25°C
Refractive Index: 1.6295
Sensitive: Moisture Sensitive
BRN: 2937608
PSA: 44.45000
LogP: 3.59620

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