Complexation of Vinylcyclopropanes with Zirconocene - 1-butene Complex: Application to the Stereocontrolled Synthesis of Steroidal Side Chains
Reactions of vinylcyclopropane derivatives with a zirconocene-1-butene complex ("Cp2Zr") caused regioselective cleavage of the cyclopropyl bond to give η3 π-allylic and/or η1 σ-allylic complexes. The regioselectivity of the bond cleavage and the formation of a η3 π-allylic or η1 σ-allylic complex depend on the bulkiness of the substituents on the cyclopropyl group and the presence of leaving functionality. A catalytic use of "Cp2Zr" in the presence of excess Grignard reagent also caused a ring opening of the vinylcyclopropane derivatives with the same sense of regiochemical selectivity. The reaction of the thermally equilibrated "Cp2Zr"-propenylcyclopropane complex with acetone indicated the possibility for the synthesis of the steroidal side chain in either natural or unnatural forms. The synthetic utility of the present μCp2Zr"-vinylcyclopropane chemistry was ascertained by the stereocontrolled preparation of the C-20, C-24 dimethylated steroidal side chain which is identical to the active metabolite of vitamin D2.
Synthesis and biological activity of a stereoisomeric mixture of the mating hormone of Phytophthora
The first synthesis of a stereoisomeric mixture of hormone α1, the mating hormone of Phytophthora, was achieved, and the synthetic mixture was confirmed to be hormonally active.
A process is described for the improved synthesis of the optically pure C10 -C18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
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(2008/06/13)
Process for synthesis of FK-506 C10-C18 intermediates
A process is described for the improved synthesis of the optically pure C10 -C18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
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(2008/06/13)
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