Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase
Previously we had shown that tripeptidyl trifluoromethyl ketones (TFMKs) possessing an N-terminal diarylacylsulfonamide, such as ICI 200,880 and ICI 200,355, displayed unparalleled protection against the lung damage induced by human neutrophil elastase (H
Edwards, Philip D.,Andisik, Donald W.,Bryant, Craig A.,Ewing, Barbara,Gomes, Bruce,Lewis, Joseph J.,Rakiewicz, Donna,Steelman, Gary,Strimpler, Ann,Trainor, Diane A.,Tuthill, Paul A.,Mauger, Russell C.,Veale, Chris A.,Wildonger, Richard A.,Williams, Joseph C.,Wolanin, Donald J.,Zottola, Mark
p. 1876 - 1885
(2007/10/03)
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