- 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.
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Paragraph 1786; 1788
(2020/02/05)
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- PYRROLIDINYL SULFONE RORGAMMA MODULATORS
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Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
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Paragraph 0247-0248
(2015/07/15)
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- Microbial Synthesis of a Tranexamic Acid Intermediate from Dinitrile
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trans-4-Cyano-cyclohexane-1-carboxylic acid (t-MCC), an intermediate in the synthesis of tranexamic acid, was found to be accumulated in the culture broth of Acremonium sp.D9K, when grown on trans-1,4-dicyano-cyclohexane as a nitrogen source.The activity of the conversion of the dinitrile to the mononitrile was inducible.The addition of an organic nitrogen source was effective for the growth of the strain, the accumulation of t-MCC and the activity of the conversion of the dinitrile by resting cells.
- Nishise, Hiroshi,Kurihara, Makoto,Tani, Yoshiki
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p. 2613 - 2616
(2007/10/02)
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