Synthesis and in vitro antitumour evaluation of benzothiazole-2- carbonitrile derivatives
Novel benzothiazole derivatives have been synthesised via the corresponding imino-1,2,3-dithiazoles. The cytotoxicity of some of these polyheterocyclic compounds was studied. Our results show that 2-cyano derivatives exhibit a medium in vitro antitumour a
Beneteau, Valerie,Besson, Thierry,Guillard, Jerome,Leonce, Stephane,Pfeiffer, Bruno
Novel 6-substituted benzothiazol-2-yl indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines
The synthetic route to and a preliminary biological evaluation of novel indolo[1,2-c]quinazolines (8) and benzimidazo[1,2-c]quinazolines (9) are described. The products were obtained by condensation of the appropriate diamines (e.g. 2-(2-aminophenyl)indol
Eco-Friendly Microwave-Assisted Scaleable Synthesis of 2-Cyanobenzothiazoles via N-Arylimino-1,2,3-dithiazoles
The cyclization procedure of N-aryl iminodithiazoles into 2-cyanobenzothiazoles was re-investigated with the aim to develop original and environmentally friendly procedures. In this article, the benefits associated with the microwave methodology are reported and the opportunity to use solvent-free procedures in order to scale up organic synthesis is studied. The result obtained show that the strong thermal effects due to graphite/microwaves interaction can be efficiently used for the synthesis of heterocyclic molecules for which traditional methods failed or are less attractive.
Frere, Stephane,Thiery, Valerie,Besson, Thierry
p. 3795 - 3804
(2007/10/03)
Rapid synthesis of 2-cyanobenzothiazoles from N-aryliminodithiazoles under microwave irradiation
Microwave irradiation of neat N-arylimino- 1,2,3-dithiazoles 2 in screwcapped glass vials gives 2-cyanobenzothiazoles 3, rapidly and cleanly in good yield.
Beneteau, Valerie,Besson, Thierry,Rees, Charles W.
p. 2275 - 2280
(2007/10/03)
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