Synthesis of alkylidenecyclopropanes via thermal cycloreversion of α-spirocyclopropyl-β-lactones
An efficient two-step synthesis of alkylidenecyclopropanes is reported based on the addition of metallated cyclopropyl thiol esters to carbonyl compounds. Thermolysis of the resulting α-spirocyclopropyl-β-lactones at 105-150°C induces thermal [2+2] cycloreversion to furnish alkylidenecyclopropanes in good yield.
Danheiser, Rick L.,Lee, Thomas W.,Menichincheri, Maria,Brunelli, Steven,Nishiuchi, Masaki
p. 469 - 470
(2007/10/03)
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