1,3-Dichloro-4,4,4-trifluorobut-2-ene as a 4-carbon building block containing a trifluoromethyl group
The preparation, isomerization, and utility of CF3CCl=CHCH2Cl as a 4-carbon reagent for the incorporation of a trifluoromethyl group is described. The regiochemistry observed for charged intermediates derived from CF3CCl=CHCH2Cl was consistent with MNDO calculated partial charges at C-1 and C-3. The anion-stabilizing and cation-destabilizing effects of the trifluoromethyl group were dominant.
Van Der Puy, Michael
p. 187 - 191
(2007/10/03)
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