- 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2
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The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
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Page/Page column 28
(2010/02/11)
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- Heterocyclic metalloprotease inhibitors
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The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metallop
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- Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors
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The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based inhibitors were discovered by optimization of hetererocyclic sulfonamide-ba
- Almstead, Neil G.,Bradley, Rimma S.,Pikul, Stanislaw,De, Biswanath,Natchus, Michael G.,Taiwo, Yetunde O.,Gu, Fei,Williams, Lisa E.,Hynd, Barbara A.,Janusz, Michael J.,Dunaway, C. Michelle,Mieling, Glen E.
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p. 4547 - 4562
(2007/10/03)
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