DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR
The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherei
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Page/Page column 75
(2008/12/05)
Facile KF/alumina mediated synthesis of α-heterosubstituted Weinreb amides
Anhydrous KF/alumina in dipolar aprotic solvents was found to be an effective promoter in the synthesis of α-heterosubstituted Weinreb amides prepared from 2-chloro-N-methoxy-N-methylacetamide. This method is high yielding, even for weak nucleophiles, and
Tius, Marcus A.,Busch-Petersen, Jakob
p. 531 - 533
(2007/10/03)
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