Diastereoselective synthesis of 2'-deoxy and 2'-O-methyl dinucleoside (3',5')-methylphosphonates via alkoxymagnesium chloride-mediated nucleoside coupling
A diastereoselective dinucleoside methylphosphonate synthetic method that features coupling of diastereomerically pure 1,1,1,3,3,3-hexafluoro-2- propyl nucleoside-3'-O-methylphosphonate monomers with 3'-O-protected nucleoside monomers mediated by alkoxymagnesium chloride reagents is described. This synthetic method was found to be diastereospecific in the synthesis of selected 2'-deoxy dinucleoside methyphosphonates and diastereoselective in the synthesis of all sixteen 2'-O-methyl dinucleoside methylphosphonates.
Get Best Price for191786-74-0(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester