- An Iodine-Mediated Hofmann-L?ffler-Freytag Reaction of Sulfoximines Leading to Dihydroisothiazole Oxides
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A Hofmann-L?ffler-Freytag type cyclization reaction of S-aryl-S-phenylpropyl sulfoximines (and related derivatives) was developed. Using molecular iodine as the initiator under visible light a series of five-membered cyclic products was obtained in moderate to high yields. The approach represents a new strategy for the synthesis of dihydroisothiazole oxides and benzo[d]isothiazoles-1-oxides. (Figure presented.).
- Zhang, Duo,Wang, Han,Cheng, Hanchao,Hernández, José G.,Bolm, Carsten
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p. 4274 - 4277
(2017/10/23)
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- A novel rapid sulfoxidation of sulfides with cyclohexylidenebishydroperoxide
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Cyclohexylidenebishydroperoxide was successfully used as the oxygen source for the oxidation of sulfides to sulfoxides for the first time. The sulfoxides were obtained in good to high yields without any detectable over-oxidation to sulfones under normal conditions.
- Jon Paul Selvam,Suresh,Rajesh,Chanti Babu,Suryakiran,Venkateswarlu
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p. 3463 - 3465
(2008/09/21)
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- α-Fluorination of methyl phenyl sulfoxide and related compounds by molecular fluorine: A novel method for the introduction of fluorine into sulfoxides bearing α-H atoms
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Direct formation of α-fluorosulfones from sulfoxides bearing α-H atoms merely by reaction with molecular fluorine (5% F2/N2) is reported, and a novel non-Pummerer-type mechanism is proposed for this α-fluorination reaction.
- Toyota, Akemi,Ono, Yoshinori,Chiba, Jun,Sugihara, Takumichi,Kaneko, Chikara
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p. 703 - 708
(2007/10/03)
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- New Synthetic Methods. Conjugate Addition of Alkyl Groups to Electron Deficient Olefins with Nitroalkanes as Alkyl Anion Equivalents
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The sequence of the Michael addition of nitroalkanes and denitration from the adduct provides a new and general method for conjugate addition of primary and secondary alkyl groups to electron deficient olefins such as α,β-unsaturated aldehydes, ketones, esters, nitriles, sulfoxides, and sulfones.
- Ono, Noboru,Kamimura, Akio,Miyake, Hideyoshi,Hamamoto, Isami,Kaji, Aritsune
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p. 3692 - 3698
(2007/10/02)
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- CONJUGATE ADDITION OF ALKYL GROUPS TO α,β-UNSATURATED SULFOXIDES VIA MICHAEL ADDITION OF NITROPARAFFINS AND SUBSEQUENT DENITRATION WITH TRIBUTYLTIN HYDRIDE
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Michael addition of nitroparaffins to α,β-unsaturated sulfoxides is well effected in the presence of DBU.The nitro group in the adduct is replaced by hydrogen with Bu3SnH without influence to the sulfinyl function.The overall reactions provide an efficien
- Ono, Noboru,Miyake, Hideyoshi,Kamimura, Akio,Tsukui, Nobuo,Kaji, Aritsune
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p. 2957 - 2960
(2007/10/02)
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