- (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction
-
A series of (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides have been synthesized and evaluated for their anticancer activity in human hepatocellular liver carcinoma HepG2 and breast adenocarcinoma MCF-7 cell lines. Among all the test
- Wang, Guangcheng,Peng, Zhiyun,Peng, Shanshan,Qiu, Jie,Li, Yongjun,Lan, Yanyu
-
supporting information
p. 3350 - 3355
(2018/09/12)
-
- Synthetic method of substituted phenyl diazene compound and application of synthetic method
-
The invention relates to a novel synthetic method of a substituted phenyl diazene compound and an application of the synthetic method. The substituted phenyl diazene compound is obtained through reduction of substituted phenyl diazonium salt; a reducing a
- -
-
Paragraph 0133; 0134
(2017/06/02)
-
- Synthesis method of substituted phenylhydrazine and salt thereof
-
The invention relates to a novel synthesis method of substituted phenylhydrazine and salt thereof. A substituted phenyl diazene compound is reduced to generate the substituted phenylhydrazine; a reducing agent B is selected from one or several of a catalytic hydrogenating system, formic acid, formate and formic acid ester compound; the obtained substituted phenylhydrazine can be further acidified to prepare the substituted phenylhydrazine salt which is easily stored and transported. The synthesis method has the advantages that the yield rate is high, the cost is low, the reaction time is short, the technology operation and post-treatment are simple, and the amount of waste water, waste gas and waste residue is fewer; the component of the produced waste water is single, the recycling is convenient, the treatment cost is low, and the green chemical requirement is met; the synthesis method of the substituted phenylhydrazine is more suitable for the large-scale industrialized production.
- -
-
Paragraph 0133; 0134
(2017/08/29)
-
- New fluorescent symmetrically substituted perylene-3,4,9,10-dianhydride- azohybrid dyes: Synthesis and spectroscopic studies
-
Five phenolic azo-dyes (3a-e) were synthesized by diazo coupling of the suitably substituted anilines (1a-e) with phenol at low temperature in alkaline medium. The resulting dyes have low solubility in aqueous medium due to lack of carboxylic or sulfonic
- Saeed, Aamer,Shabir, Ghulam
-
-
- Parallel synthesis of "Click" chalcones as antitubulin agents
-
It has been shown that some chalcones are able to inhibit tubulin polymerization, giving cytotoxicity and destruction of tumoral vasculature. A library of 180 novel chalcone analogs has been synthesized via click chemistry and screened for their cytotoxic
- Utsintong, Maleeruk,Massarotti, Alberto,Caldarelli, Antonio,Theeramunkong, Sewan
-
p. 510 - 516
(2013/07/28)
-
- Aromatic heterocyclic derivatives as enzyme inhibitors
-
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
- -
-
Page column 124
(2010/02/04)
-
- Reaction of Triazene 1-Oxides: Novel Synthesis of Solid Arenediazonium Chlorides
-
Treatment of 1,3-diaryltriazene 1-oxides with oxalyl chloride in dry toluene at room temperature gives only solid arenediazonium chlorides; however, treatment with acetyl and benzoyl chlorides does not afford the corresponding diazonium chlorides.
- Mohamed, Shaaban K.,Gomaa, Mohsen A.-M.,Nour El-Din, Ahmed M.
-
p. 166 - 167
(2007/10/03)
-
- FORMATION OF ARENEDIAZONIUM ION IN OXIDATION OF N,N-DIMETHYL-4-AMINOBENZENE AND SOME meta-SUBSTITUTED DERIVATIVES WITH CERIMU(IV) ION IN ACID MEDIUM
-
Oxidation has been studied of an experimental hepatocarcinogene N,N-dimethyl-4-aminoazobenzene and some its meta-substituted derivatives with cerium(IV) ion in 1M hydrochloric acid medium with potentiometric indication.It has been possible to prove format
- Matrka, Miroslav,Pipalova, Jitka
-
p. 2711 - 2715
(2007/10/02)
-