19235-17-7

Basic information

• Product Name: 5-HydroxyMethyl cytidine
• Synonyms: 5-HydroxyMethyl cytidine;NFEXJLMYXXIWPI-WJZMDOFJSA-N
• CAS NO: 19235-17-7
• Molecular Formula: C₁₀H₁₅N₃O₆
• Molecular Weight: 273.2426
• Mol File: 19235-17-7.mol

Chemical Properties

• Melting Point: 215 °C (decomp)
• Boiling Point: 621.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
• PKA: 13.47±0.10(Predicted)
• CAS DataBase Reference: 5-HydroxyMethyl cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HydroxyMethyl cytidine(19235-17-7)
• EPA Substance Registry System: 5-HydroxyMethyl cytidine(19235-17-7)

Safety Data

• Hazardous Substances Data: 19235-17-7(Hazardous Substances Data)

Usage

Uses

Used in Biomedical Research:
5-HydroxyMethyl cytidine is used as a biomarker for studying neurological disorders, particularly Alzheimer's disease. The concentrations of 5-HMC in the brain can help researchers understand the epigenetic changes associated with the disease and potentially identify novel therapeutic targets for treatment.
Used in Epigenetic Studies:
5-HydroxyMethyl cytidine is used as an epigenetic marker for investigating gene regulation, cellular differentiation, and embryonic development. By analyzing the distribution and levels of 5-HMC in various cell types and tissues, researchers can gain insights into the epigenetic mechanisms underlying these processes and identify potential regulatory elements.
Used in Drug Development:
5-HydroxyMethyl cytidine can be used as a target for the development of drugs that modulate the epigenetic landscape. By targeting enzymes involved in the formation, maintenance, or removal of 5-HMC, researchers can potentially develop therapies for various diseases, including cancer and neurological disorders.
Used in Diagnostics:
5-HydroxyMethyl cytidine can be used as a diagnostic marker for various diseases, including cancer and neurological disorders. By measuring the levels of 5-HMC in biological samples, clinicians can potentially identify disease-specific epigenetic signatures that can aid in early detection, prognosis, and personalized treatment strategies.
Used in Genomic Technologies:
5-HydroxyMethyl cytidine is used as a key component in the development of next-generation sequencing technologies, such as bisulfite sequencing and oxidative bisulfite sequencing. These techniques allow for the precise mapping of 5-HMC and other epigenetic marks in the genome, enabling researchers to study the epigenetic landscape at a single-base resolution.

Upstream product

• 2140-61-6 5-methylcytidine 
• 1123-95-1 5-hydroxymethylcytosine 
• 13035-61-5 1,2,3,5-tetraacetylribose 

Downstream Products

• 148608-53-1 5-formylcytidine 

Relevant articles and documents

SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS

This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.

Oxidation of Cytosine and 5-Methylcytosine Nucleosides and 5-Methyl-2'-deoxycytidine 5'-Monophosphate with Peroxosulfate Ions

Reaction of 5-methylcytosine nucleosides and nucleotide with Na2S2O8 resulted in an oxidation of the 5-methyl group, while treatment of them and cytosine nucleosides with KHSO5 gave the corresponding N3-oxides.

MECHANISMS FOR THE SOLVOLYTIC DECOMPOSITIONS OF NUCLEOSIDE ANALOGUES-VIII. ACIDIC HYDROLYSIS OF 5-SUBSTITUTED 1-(ALKOXYETHYL)CYTOSINES AND CYTIDINES

Several 5-substituted 1-(1-alkoxyethyl)cytosines have been prepared and the rate constants for their hydrolysis determined at various concentration of oxonium ion.The acidity constants for the monoprotonated substrates and the rate constants for their decomposition have been calculated from the pH-rate profiles obtained.The effects that varying the polar nature of the 1-alkoxyethyl group exerts on the heterolysis of the monoprotonated substrates are interpreted to indicate that the acidic hydrolysis of 1-(1-alkoxyethyl)cytosines proceeds by rate-limiting departure of protonated base moiety with formation of an oxocarbenium ion intermediate.The same mechanism is extended to the hydrolysis of cytidines by comparing the influences that the 5-substituents have on the heterolysis of protonated 5-substituted 1-(1-ethoxyethyl)cytosines and correspondingly substituted cytidines.