19269-28-4Relevant articles and documents
Lubricant and fuel dispersants and methods of preparation thereof
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Page/Page column 38, (2018/07/29)
This disclosure relates to a composition for use as an additive for fuels and lubricants including a reductive amination product of a vinyl terminated macromonomer (VTM) based aldehyde. Optionally aldehyde is reacted with the amino compound under condensation conditions sufficient to give an imine intermediate, and the imine intermediate is reacted under hydrogenation conditions sufficient to give the composition. The aldehyde is formed by reacting a VTM under hydroformylation conditions sufficient to form the aldehyde. A reductive amination method for making a composition for use as an additive for fuels and lubricants. The method includes reacting a VTM based aldehyde with an amino compound containing at least one —NH— group under condensation conditions sufficient to give an imine intermediate, and reacting the imine intermediate under hydrogenation conditions sufficient to give said composition. The aldehyde is formed by reacting a VTM under hydroformylation conditions sufficient to form the aldehyde.
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships
Horiuchi, Takao,Takeda, Yasuyuki,Haginoya, Noriyasu,Miyazaki, Masaki,Nagata, Motoko,Kitagawa, Mayumi,Akahane, Kouichi,Uoto, Kouichi
experimental part, p. 991 - 1002 (2011/10/02)
The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure-activity relationships of our synthetic compounds are discussed.
REACTION OF α,β-UNSATURATED ALDEHYDES WITH HYDROGEN PEROXIDE CATALYSED BY BENZENESELENINIC ACIDS AND THEIR PRECURSORS
Syper, Ludwik
, p. 2853 - 2872 (2007/10/02)
Oxidation of α,β-unsaturated aldehydes with hydrogen perixide catalysed by benzeneselenic acids and their precursors has been investigated.Bis 2-nitrophenyl diselenide has proved to be the most effective catalyst.The major products resulting from the oxidation are vinyl formates (a) which on hydrolysis give saturated aldehydes or ketones (g) having the carbon chain shortened by one carbon atom, compared with the starting aldehydes.The minor products are formyloxyoxiranes (b), α-hydroxycarbonyl (e) and α-formyloxycarbonyl (f) compounds with the carbon chain shortened by one carbon atom.Carbonyl compounds d, formally derived from an oxidative fission of the carbon-carbon double bond, have been also isolated.Diformyloxy (4c) and formyloxyacetoxy phenylmethane (5c) have been isolated when cinnamaldehyde (4) or 1-phenyl-2-formyloxypropane (5a) were oxidized, respectively.Possible mechanisms of formation of these products are discussed.Similar products resulted when α,β-unsaturated aldehydes were oxidized with organic peroxy acids.
Vapor Pressures, Liquid Densities, Liquid Heat Capacities, and Ideal Gas Thermodynamic Properties for 3-Methylhexanal and 3,4-Dimethylpentanal
Mills, Patrick L.,Fenton, Ricky L.
, p. 266 - 273 (2007/10/02)
Vapor pressures, liquid densities, and liquid heat capacities were measured for 3-methylhexanal and 3,4-dimethylpentanal which are two of several C7 aldehyde reaction products that can be obtained from the hydroformylation of hexenes using cobalt or rhodium homogeneous catalyst precursors.The vapor pressure data were fitted to the Miller and Antoine equations and also compared to predictions obtained form the Riedel-Plank-Miller equation.Values for the critical temperature and critical pressure were derived by group contribution methods and compared to independent values obtained by fitting the vapor pressure data to the Riedel-Plank-Miller equation and two corresponding-states-based equations.The liquid density data were compared to predictions obtained from the Yen-Woods equation and were also fitted to an empirical equation.Predictions from the Sternling-Brown, Yuan and Stiel, and the Rowlinson corresponding-state correlations were in good agreement with the liquid heat capacity data, although an empirical polynomial equation was also tested and had a lower mean deviation.Ideal gas thermodynamic properties were also derived and were used to calculate some of the predicted quantities.
ADDITION D'ORGANOCUPRATES AUX OXAZOLIDINES CHIRALES α-β ETHYLENIQUES : I - RESULTATS - EFFETS DE SEL ET DE SOLVANT
Berlan, J.,Besace, Y.,Pourcelot, G.,Cresson, P.
, p. 4757 - 4766 (2007/10/02)
Organocuprates add quantitatively to oxazolidines I.The steric course of the reaction can be reversed and the diastereoselectivity enhanced by salt effect and (or) by solvent effect.
ACTION DES DIALKYLCUPRATES DE LITHIUM SUR LES ALDEHYDES α,β-ETHYLENIQUES
Chuit, C.,Foulon, J. P.,Normant, J. F.
, p. 2305 - 2310 (2007/10/02)
Nearly exclusive 1-4 addition products are obtained by action of lithium dialkylcuprates with α,β-ethylenic aldehydes.Non polar solvents and low temperatures favor this reaction.Only α,β-ethylenic aldehydes having a trisubstituted double bond give a relatively important proportion of 1-2 addition product.
