1927-95-3

Basic information

• Product Name: 4-BROMOPHENOL ACETATE
• Synonyms: p-bromophenylacetate;Phenol, p-bromo-, acetate;4-BROMOPHENYLACETATE;4-BROMOPHENOL ACETATE;4-Bromophenylacetate, 98 %;4-Bromo-1-acetoxybenzene;Acetic acid p-bromophenyl ester;(4-bromophenyl) ethanoate
• CAS NO: 1927-95-3
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.04
• EINECS: 217-668-6
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 1927-95-3.mol

Chemical Properties

• Melting Point: 21.5 °C
• Boiling Point: 251℃
• Flash Point: 106℃
• Appearance: white like or light brown crystalline powder
• Density: 1.501
• Vapor Pressure: 0.0211mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMOPHENOL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPHENOL ACETATE(1927-95-3)
• EPA Substance Registry System: 4-BROMOPHENOL ACETATE(1927-95-3)

Safety Data

• Hazardous Substances Data: 1927-95-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromophenol acetate is used as a building block for the synthesis of various pharmaceuticals, leveraging its reactivity in chemical reactions to form complex molecules that can be used as active ingredients in medications.
Used in Agrochemical Industry:
4-Bromophenol acetate is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, where its chemical properties are harnessed to create compounds that can protect crops from pests and diseases.
Used in Organic Synthesis:
4-Bromophenol acetate is used as a versatile intermediate in organic synthesis, where its bromine atom and acetate group enable it to participate in a range of reactions, including nucleophilic substitutions and cross-coupling reactions like the Suzuki reaction, to form diverse organic compounds.
Used in Chemical Research:
4-Bromophenol acetate is used as a model compound in chemical research, allowing scientists to study reaction mechanisms and explore new synthetic pathways, which can lead to the discovery of novel compounds and materials.

InChI:InChI=1/C8H7BrO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

Upstream product

• 56-23-5 tetrachloromethane 
• 128-08-5 N-Bromosuccinimide 
• 122-79-2 Phenyl acetate 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 106-41-2 4-bromo-phenol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 127-09-3 sodium acetate 
• 108-05-4 vinyl acetate 
• 17878-44-3 (4-bromophenoxy)trimethylsilane 
• 506-96-7 Acetyl bromide 
• 121824-43-9 1-((methylsulfinyl)methoxy)-4-bromobenzene 
• 99-90-1 para-bromoacetophenone 
• 64-19-7 acetic acid 

Downstream Products

• 106-41-2 4-bromo-phenol 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 89510-71-4 (E,E,E)-1,6-bis-(p-acetoxyphenyl)-1,3,5-hexatriene 
• 2628-16-2 p-acetoxystyrene 
• 3886-80-4 N-acetyl-1-dodecylamine 
• 802294-64-0 propionic acid 
• 7693-52-9 4-bromo-2-nitrophenol 
• 123871-60-3 4-Bromo-4-nitro-cyclohexa-2,5-dienone 
• 64-19-7 acetic acid 
• 164409-34-1 p-Acetoxy α,β,β-trifluorostyrene 
• 25244-30-8 4-(allyloxy)bromobenzene 
• 25944-72-3 diethyl p-acetoxyphenylphosphonate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 25458-45-1 p-methoxymethoxybromobenzene 

Relevant articles and documents

Chromone dioxadiazole compound as well as preparation method and application thereof

The preparation method comprises the following steps: adding an intermediate F and bis (acetoxy) iodobenzene to dichloromethane for reaction to obtain the chromone compound. The invention provides a novel chromone dioxadiazole compound and a preparation method thereof, and overcomes the defects of large toxicity and high preparation cost of the traditional method.

Steric effect of NHC ligands in Pd(II)–NHC-catalyzed non-directed C–H acetoxylation of simple arenes

Although there has been a lot of progress in oxidative arene C–H functionalization reactions catalyzed by Pd(II/IV) system, the non-directed, site-selective functionalization of arene molecules is still challenging. It has been established that ligands play a pivotal role in controlling rate- as well as selectivity-determining step in a catalytic cycle involving well-defined metal-ligand bonding. N-heterocyclic carbene (NHC) ligands have had a tremendous contribution in the recent extraordinary success of achieving high reactivity and excellent selectivity in many catalytic processes including cross-coupling and olefin-metathesis reactions. However, the immense potential of these NHC ligands in improving site-selectivity of non-directed catalytic C–H functionalization reactions of simple arenes is yet to be realized, where overriding the electronic bias on deciding selectivity is a burdensome task. The presented work demonstrated an initiative step in this regard. Herein, a series of well-defined discrete [Pd(NHCR′R)(py)I2] complexes with systematically varied degree of spatial congestion at the Pd centre, exerted through the R and R’ substituents on the NHC ligand, were explored in controlling the activity as well as the site-selectivity of non-directed acetoxylation of representative monosubstituted and disubstituted simple arenes (such as toluene, iodobenzene and bromobenzene, naphthalene and 1,2-dichlorobenzene). The resulting best yields were found to be 75% for toluene and 65% for bromobenzene with [Pd(NHCMePh)(py)I2], 75% for iodobenzene and 79% for naphthalene with [Pd(NHCMeMe)(py)I2], and 41% for 1,2-dichlorobenzene with [Pd(NHCCyCy)(py)I2]. Most importantly, with increasing the bulkiness of the NHC ligand in the complexes, the selectivity of the distal C-acetoxylated products in comparison to the proximal ones, was enhanced to a great extent in all cases. Considering the vast library of NHC ligands, this study underscores the future opportunity to develop more strategies to improve the activity and the crucial site-selectivity of C–H functionalization reactions in simple as well as complex organic molecules.

Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates

Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.

(4-HYDROXYPYRROLIDIN-2-YL)-HYDROXAMATE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.

Polymerizable compound having conjugated bonds, liquid crystal composition and liquid crystal display device

Subject It is to provide a polymerizable compound having a high polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition, a polymerizable composition including this compound, a liquid crystal composite prepared from this polymerizable composition and a liquid crystal display device containing this composite. Means for solving the Subject A compound represented by formula (1), the liquid crystal composition and the liquid crystal display device. In the formula, for example, ring A1, ring A2 and ring A4 are phenylene or cyclohexylene; Sp1 and Sp2 are a single bond or alkylene having 1 to 6 carbons; Z1 and Z2 are —CH═CH— or —C≡C—; a is 1, b is 0; and P1 and P2 are a polymerizable group.

Semi-heterogeneous Dual Nickel/Photocatalysis using Carbon Nitrides: Esterification of Carboxylic Acids with Aryl Halides

Cross-coupling reactions mediated by dual nickel/photocatalysis are synthetically attractive but rely mainly on expensive, non-recyclable noble-metal complexes as photocatalysts. Heterogeneous semiconductors, which are commonly used for artificial photosynthesis and wastewater treatment, are a sustainable alternative. Graphitic carbon nitrides, a class of metal-free polymers that can be easily prepared from bulk chemicals, are heterogeneous semiconductors with high potential for photocatalytic organic transformations. Here, we demonstrate that graphitic carbon nitrides in combination with nickel catalysis can induce selective C?O cross-couplings of carboxylic acids with aryl halides, yielding the respective aryl esters in excellent yield and selectivity. The heterogeneous organic photocatalyst exhibits a broad substrate scope, is able to harvest green light, and can be recycled multiple times. In situ FTIR was used to track the reaction progress to study this transformation at different irradiation wavelengths and reaction scales.

Highly efficient Sandmeyer reaction on immobilized CuI/CuII-based catalysts

Highly effective embodiment of Sandmeyer reaction has been revealed for Cu-based catalysts incorporating ionic liquid on Silochrom support. The most active catalyst (TOF = = 4000–8000 h–1) contains comparable amounts of cuprous and cupric chloride anions. The reported method allows one to carry out the reaction for anilines in the one-pot mode.

Preparation method for synthesis of phenolic ester through thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction

The invention discloses a preparation method for synthesis of phenolic ester through a thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction. Thiocarboxylic acid compounds andphenol compounds are subjected to a site specific reaction under certain conditions to produce phenolic ester compounds, wherein the certain conditions are as follows: under the conditions of normaltemperature, normal pressure and visible light, K2CO3 is used as an alkaline catalyst, terpyridyl ruthenium dichloride hexahydrate is used as a photosensitizer and acetonitrile is used as a reaction solvent. Synthesis of phenolic ester under catalysis of visible light is realized, thiocarboxylic acid is used as an acylation reagent, and the site specific phenol esterification reaction is realizedefficiently under mild conditions of normal temperature, normal pressure and visible light. The method has mild reaction conditions, large substrate functional group tolerance, high applicability andhigh yield, and an efficient, reliable and economical preparation method is provided for synthesis of phenolic ester.

Size-selective catalysts in five functionalized porous coordination polymers with unsaturated zinc centers

The five reported structural isomorphic porous coordination polymers (PCPs) 1-5, namely, [Zn(L)(ip) (1), Zn(L)(aip) (2), Zn(L)(hip) (3), Zn(L)(nip) (4), and Zn(L)(HBTC) (5) (L = N4,N4′-di(pyridine-4-yl)biphenyl-4,4′-dicarboxamide, H2ip = isophthalic acid, H2aip = 5-aminoisophthalic acid, H2hip = 5-hydroxyisophthalic acid, H2nip = 5-nitroisophthalic acid, H3BTC = 1,3,5-benzenetricarboxylic acid)] were used to catalyze the acetylation of phenol. All these heterogeneous catalysts exhibit good catalytic efficiency and size-selectivity toward the acetylation of phenols owing to their unsaturated metal centers, non-coordinated amide, and suitable channel size and shape. Among them, 2 displays the highest catalytic activity and excellent cooperative catalysis due to the presence of basic non-coordinated amide groups.

Cu (I)-based metal organic coordination polymer and preparation method and application thereof

The invention discloses organic ligand L for synthesizing Cu (I)-based metal organic coordination polymer, and Cu (I)-based metal organic coordination polymers Cu-CPs; the meal organic coordination polymers Cu-CPs are synthesized through the organic ligand L and are of 1D single-stranded structure, having two crystallographically independent Cu metal centers, with one center positioned on 1D strand and connecting imidazole N atoms on two ligands, and with the other positioned outside the 1D strand and having two Br ligands present in the form of [CuBr2]-. There is weak M-M action between the two Cu metal centers. The Cu-CPs are efficient in catalyzing phenylethylene oxide ring-opening reaction, p-bromophenol acetylization and Mannich reaction with no need for heavy metals to engage in catalyst reaction, environmental damage due to heavy metals is reduced, reaction temperature is medium, reaction time is short, little catalyst is used, no other additives are used, and compared with free heavy metal salts, the polymers are available for more than 5 times of reuse.