19275-44-6

Basic information

• Product Name: 1-Isomangostin
• Synonyms: 1-Isomangostin
• CAS NO: 19275-44-6
• Molecular Formula: C24H26O6
• Molecular Weight: 410.463
• Mol File: 19275-44-6.mol

Chemical Properties

• Melting Point: 155-156 °C
• Boiling Point: 613.9 °C at 760 mmHg
• Flash Point: 211.5 °C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 1.16E-15mmHg at 25°C
• Refractive Index: 1.604
• PKA: 7.28±0.40(Predicted)
• CAS DataBase Reference: 1-Isomangostin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Isomangostin(19275-44-6)
• EPA Substance Registry System: 1-Isomangostin(19275-44-6)

Safety Data

• Hazardous Substances Data: 19275-44-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Isomangostin is used as a pharmaceutical agent for its potential anti-inflammatory, antioxidant, and anticancer properties. Its ability to modulate various biological pathways and target specific enzymes makes it a promising candidate for the development of new drugs to treat various diseases.
Used in Cosmetic Industry:
1-Isomangostin is used as an active ingredient in cosmetic products for its potential skin-whitening and anti-aging effects. Its antioxidant and anti-inflammatory properties contribute to the protection and rejuvenation of the skin, making it a valuable component in skincare formulations.
Used in Food Industry:
1-Isomangostin is used as a natural preservative and antioxidant in the food industry. Its ability to inhibit the growth of microorganisms and prevent oxidation of food products helps to extend their shelf life and maintain their quality.
Used in Agricultural Industry:
1-Isomangostin is used as a biopesticide in the agricultural industry due to its potential insecticidal and antimicrobial properties. It can help protect crops from pests and diseases, promoting sustainable agriculture practices.

InChI:InChI=1/C24H26O6/c1-12(2)6-7-14-19-17(11-16(26)22(14)28-5)29-18-10-15(25)13-8-9-24(3,4)30-23(13)20(18)21(19)27/h6,10-11,25-26H,7-9H2,1-5H3

Upstream product

• 6147-11-1 α-mangostin 

Relevant articles and documents

Modified tetra-oxygenated xanthones analogues as anti-MRSA and P. aeruginosa agent and their synergism with vancomycin

Five isolated xanthones from the C. cochinchinense and G. mangostana were evaluated and tested for antibacterial activities. Isolated 4 and 5 exhibited potent anti-MRSA and P. aeruginosa activity, but showed poor pharmacokinetic properties via ADMET prediction. It led us to improve pharmacokinetic properties of 4 and 5 by partially modifying them in acidic condition yielding fourteen analogues. It was found that analogues 4b, 4d and 5b possessed proper pharmacokinetic properties, while only 4b exhibited the best anti-MRSA and P. aeruginosa activity. The SEM results indicated that 4b may interact with or damage the cell wall of MRSA and P. aeruginosa. Moreover, a combination of 4b and vancomycin exhibits synergistic effect against both MRSA and P. aeruginosa at MIC value of 4.98 (MIC = 18.75 μg/mL for 4b) and 9.52 μg/mL (MIC = 75 μg/mL for 4b), respectively.

Design, synthesis and structure-activity relationships of mangostin analogs as cytotoxic agents

In order to better understand the structure-activity relationship of mangostin, a series of xanthone derivatives based on α-mangostin were designed and synthesized. All the compounds were evaluated for their cytotoxicity against a panel of five human canc

Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana

α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, but present in the molecule in multiple instances (three phenolic hydroxyl groups, two prenyl chains and two unsubstituted aromatic carbons). This study represents a first approach to the systematic investigation of the reactivity of α-mangostin and describes the semisynthesis of some minor xanthones isolated from G. mangostana.

Bicyclomangostin: A new acid-catalysed cyclization product from mangostin

Cyclization of mangostin with p-toluenesulfonic acid gave 1-isomangostin, 3-isomangostin, and a new cyclization product, bicyclomangostin (4). The structure of bicyclomangostin was determined by spectroscopic and X-ray crystallographic studies. The methyl ether derivatives (8) and (9) or (10) were produced on methylation of bicyclomangostin, depending on the method used.