192819-46-8

Basic information

• Product Name: 1,3-Benzenediamine,4-fluoro-N1,N1-dimethyl-(9CI)
• Synonyms: 1,3-Benzenediamine,4-fluoro-N1,N1-dimethyl-(9CI)
• CAS NO: 192819-46-8
• Molecular Formula: C₈H₁₁FN₂
• Molecular Weight: 154.1847432
• Product Categories: HALIDE
• Mol File: 192819-46-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Benzenediamine,4-fluoro-N1,N1-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenediamine,4-fluoro-N1,N1-dimethyl-(9CI)(192819-46-8)
• EPA Substance Registry System: 1,3-Benzenediamine,4-fluoro-N1,N1-dimethyl-(9CI)(192819-46-8)

Safety Data

• Hazardous Substances Data: 192819-46-8(Hazardous Substances Data)

Usage

Synonyms

4-Fluoro-3,3-dimethylaniline

Class

Aromatic amines

Derivative of

Aniline

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Production of dyes
d. Production of pigments
e. Production of polymers

Safety precautions

a. Potential toxic and harmful effects
b. Proper handling and storage required
c. Cautions in laboratory and industrial settings to prevent exposure and adverse health effects

Upstream product

• 18542-98-8 4-fluoro-N,N-dimethyl-3-nitroaniline 

Downstream Products

• 69922-27-6 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene 
• 890435-04-8 1-(5-bromopyridin-2-yl)-3-(2-fluoro-5-trifluoromethylphenyl)urea 
• 890435-03-7 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]urea 

Relevant articles and documents

N-Heterocyclic Carbene Catalyzed Concerted Nucleophilic Aromatic Substitution of Aryl Fluorides Bearing α,β-Unsaturated Amides

Concerted nucleophilic aromatic substitution (CSNAr) has emerged as a powerful mechanistic manifold, in which nucleophilic aromatic substitution can proceed in one step without the need to form a Meisenheimer intermediate. However, all of the CSNAr reactions reported thus far require a stoichiometric strong base or activating reagent, and no catalytic variants have yet been reported. Herein, we report an N-heterocyclic carbene (NHC)-catalyzed intramolecular cyclization of acrylamides that contain a 2-fluorophenyl group on the nitrogen through a CSNAr reaction. By using this catalytic method, it is possible to synthesize an array of quinolin-2-one derivatives, which are common structural motifs in pharmaceuticals and organic materials. DFT calculations unambiguously revealed that this reaction proceeds through the concerted nucleophilic aromatic substitution of aryl fluorides, in which a stereoelectronic σ (Cipso-Cβ)→ σ*(Cipso-F) interaction critically contributes to the stabilization of the transition state for the cyclization.

Substituent effects on the isomerization of hydrazone switches driven by the intramolecular hydrogen bond

In this work, the substituent effects on hydrogen bonding in one kind of hydrazone-based switch are revealed. The E/Z isomerization ratios of these hydrazones and their intramolecular hydrogen bond strengths in the Z form were evaluated using NMR technique. Linear correlations between these parameters and Hammett empirical values for substituent effects are explored as well.

NOVEL SULFONAMIDE COMPOUNDS

The invention relates to novel sulfonamide compounds and their use as orexin receptor antagonists.

Substituted Indoles, Compositions Containing Them, Method for the Production Thereof and Their Use

Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as antican

NOVEL SULFONAMIDE COMPOUNDS

The invention relates to sulfonamide compounds of formula (I), where A, B, R3 and R4 are as defined in the claims, and their use as orexin receptor antagonists in the prevention and treatment of eating and drinking disorders, all types of sleep disorders, all kinds of cognitive dysfunctions in the healthy population and psychiatric and neurologic disorders. Formula (I).