192862-16-1

Basic information

• Product Name: Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI)
• Synonyms: Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI)
• CAS NO: 192862-16-1
• Molecular Formula: C₉H₈F₂OS
• Molecular Weight: 202.2210264
• Product Categories: ACETYLHALIDE
• Mol File: 192862-16-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI)(192862-16-1)
• EPA Substance Registry System: Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI)(192862-16-1)

Safety Data

• Hazardous Substances Data: 192862-16-1(Hazardous Substances Data)

Upstream product

• 5398-93-6 2-methylthio-1-phenyl-ethanone 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 5188-07-8 sodium thiomethoxide 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 5188-07-8 sodium methylmercaptan 

Downstream Products

• 192862-21-8 2-[difluoro(methylthio)methyl]-2-phenyloxirane 
• 192861-90-8 1,1-difluoro-1-(methylthio)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)-2-propanol 

Relevant articles and documents

Process for the production of fluorinated organic compounds and fluorinating agents

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Fluorination of sulfides using IF5-Et3N-3HF

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New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).

Triazole derivative and pharmaceutical comprising the same as an effective ingredient

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